Portal Orlando, Clark William A, Levinson Dennis J
Department of Medicine, Michael Reese Hospital, Chicago, Illinois; Email:
Wounds. 2009 Jan;21(1):1-3.
Following standard care, nonhealing lower extremity (LE) ulcers were managed with a bacterial cellulose (BC) wound dressing, Dermafill™, (AMD/Ritmed, Tonawanda, NY), derived from Acetobacter xylinum. The time to 75% reduction in wound size was compared in 11 chronic wounds before and after the application of BC. The mean period of observation before the application of BC was 315 days; (95% CI: 239-392 days). With the application of BC to these chronic wounds, the mean time to 75% epithelization was reduced to 81 days (95% CI: 50-111 days) with a median of 79 days. The rate of wound closure with BC was significantly faster than with standard care (P < 0.001). When applied to nonhealing LE ulcers, a BC wound dressing shortens the time to wound closure over standard care.
按照标准护理方法，采用源自木醋杆菌的细菌纤维素（BC）伤口敷料Dermafill™（AMD/Ritmed，纽约州托纳旺达）处理不愈合的下肢（LE）溃疡。比较了11处慢性伤口在使用BC前后伤口大小减少75%所需的时间。使用BC前的平均观察期为315天；（95%置信区间：239 - 392天）。对这些慢性伤口使用BC后，伤口上皮化达到75%的平均时间缩短至81天（95%置信区间：50 - 111天），中位数为79天。使用BC时伤口闭合的速度明显快于标准护理（P < 0.001）。当应用于不愈合的LE溃疡时，BC伤口敷料比标准护理能缩短伤口闭合的时间。
