Sertić Milić Helga, Franjević Ana, Bubanović Gordana, Marušić Ante, Nikolić Igor, Puljić Igor
Clinical Department for Diagnostic and Interventional Radiology, University Hospital Centre Zagreb, Zagreb, Croatia.
Wien Klin Wochenschr. 2015 Jun;127(11-12):465-71. doi: 10.1007/s00508-014-0678-2. Epub 2015 Apr 28.
The computed tomography (CT) is the "golden standard" for the assessment of lung cancer progression due to its ability to clearly display the radiomorphologic characteristics. As lung cancer mortality is very high, more comprehensive approaches may be needed for its earlier diagnosis. The research hypothesis was to investigate the relation between the CT morphologic characteristics (size, stage, and edges) of pulmonary lesion and the extent of release of a soluble fragment of cytokeratin 19 being a part of the cytoskeleton of lung epithelial cells.
This is a retrospective study including 246 pulmonary lesions being diagnosed and subsequently treated at the University Hospital Centre Zagreb, Croatia. The information about the relevant clinical, radiological, and laboratory facts was collected at the time of diagnosis in 164 NSCLC patients, 52 patients with pulmonary metastases, and 30 benign cysts. CYFRA 21-1 was determined by electrochemiluminescence immunoassay. The nonparametric statistical methods were applied.
There was a positive correlation between the size and CYFRA 21-1 in NSCLC unlike metastases or cysts (p = 0.0001). The highest values of CYFRA 21-1 were seen in advanced stages of NSCLC and lesions with spiculated edges.
The level of CYFRA 21-1 positively correlates with the greatest size of NSCLC measured by CT. The differences in CYFRA 21-1 according to TNM classification are significant (p = 0.0001): higher values were observed in advanced stages and with tumors having spiculated, lobulated, and poorly defined edges. The combination of CYFRA 21-1 and CT may help articulate the malignancy of pulmonary lesions.
计算机断层扫描（CT）因其能够清晰显示放射形态学特征，是评估肺癌进展的“金标准”。由于肺癌死亡率很高，可能需要更全面的方法来进行早期诊断。本研究假设是探讨肺部病变的CT形态学特征（大小、分期和边缘）与作为肺上皮细胞细胞骨架一部分的细胞角蛋白19可溶性片段释放程度之间的关系。
这是一项回顾性研究，纳入了在克罗地亚萨格勒布大学医院中心诊断并随后接受治疗的246例肺部病变。在诊断时收集了164例非小细胞肺癌患者、52例肺转移患者和30例良性囊肿患者的相关临床、放射学和实验室资料。采用电化学发光免疫分析法测定细胞角蛋白片段21-1（CYFRA 21-1）。应用非参数统计方法。
与转移瘤或囊肿不同，非小细胞肺癌中CYFRA 21-1与大小呈正相关（p = 0.0001）。CYFRA 21-1的最高值见于非小细胞肺癌晚期和边缘有毛刺的病变。
CYFRA 21-1水平与CT测量的非小细胞肺癌最大大小呈正相关。根据TNM分类，CYFRA 21-1的差异具有显著性（p = 0.0001）：在晚期以及肿瘤边缘有毛刺、分叶和边界不清的情况下观察到较高的值。CYFRA 21-1与CT的联合应用可能有助于明确肺部病变的恶性程度。
