Slaoui Meriem, El Mzibri Mohammed, Razine Rachid, Qmichou Zineb, Attaleb Mohammed, Amrani Mariam
Equipe de recherche ONCOGYMA, University of Mohamed V-Souissi, Faculty of Medicine and Pharmacy of Rabat, Avenue Mohammed Belarbi El Alaoui - Souissi, BP 6203 Rabat, Morocco ; Unité de Biologie et Recherche Médicale, Centre National de l'Energie, des Sciences et des Techniques Nucléaires, Rabat, Morocco.
Unité de Biologie et Recherche Médicale, Centre National de l'Energie, des Sciences et des Techniques Nucléaires, Rabat, Morocco.
Infect Agent Cancer. 2014 Nov 10;9:37. doi: 10.1186/1750-9378-9-37. eCollection 2014.
The mouse mammary tumor virus (MMTV) like sequences have been reported to be present in some human breast cancers, but their association with breast cancer development is still controversial.
In this retrospective study, we investigated the status of MMTV-like in 42 tumor biopsies and 18 paired normal tissues from Moroccan patients with breast cancer. MMTV-like env sequences were identified by PCR and confirmed by direct DNA sequencing.
Specific MMTV-like env sequences were found in 24 (57.14%) cases of breast carcinomas, and 6 (33.3%) cases of matched normal breast tissues. Comparison to sociologic and clinicopathological parameters showed no significant association between the presence of MMTV-like sequences and age, menopausal status, histological subtype, histological grade, tumor size and the expression of hormone receptors (estrogen ER and/or progesterone PgR) and Her 2. However, a significant correlation was found between MMTV-like presence and parity (p = 0.024).
This present study confirms the presence of MMTV-like env sequences in breast cancer in Moroccan women, prompting further evaluation, on large sampling, to elucidate the probable causal roles of MMTV-like in breast cancer development.
据报道，一些人类乳腺癌中存在小鼠乳腺肿瘤病毒（MMTV）样序列，但其与乳腺癌发生的关联仍存在争议。
在这项回顾性研究中，我们调查了42例摩洛哥乳腺癌患者的肿瘤活检组织和18对配对正常组织中MMTV样序列的情况。通过PCR鉴定MMTV样env序列，并通过直接DNA测序进行确认。
在24例（57.14%）乳腺癌病例和6例（33.3%）配对的正常乳腺组织中发现了特异性MMTV样env序列。与社会学和临床病理参数的比较显示，MMTV样序列的存在与年龄、绝经状态、组织学亚型、组织学分级、肿瘤大小以及激素受体（雌激素ER和/或孕激素PgR）和Her 2的表达之间无显著关联。然而，发现MMTV样序列的存在与产次之间存在显著相关性（p = 0.024）。
本研究证实了摩洛哥女性乳腺癌中存在MMTV样env序列，促使进一步进行大样本评估，以阐明MMTV样序列在乳腺癌发生中可能的因果作用。
