葫芦脲是一种超灵敏的（129）Xe NMR 对比剂。
Cucurbit[6]uril is an ultrasensitive (129)Xe NMR contrast agent.
机构信息
Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
出版信息
Chem Commun (Camb). 2015 May 28;51(43):8982-5. doi: 10.1039/c5cc01826a.
Abstract
A lack of molecular contrast agents has slowed the application of ultrasensitive hyperpolarized (129)Xe NMR methods. Here, we report that commercially available cucurbit[6]uril (CB[6]) undergoes rapid xenon exchange kinetics at 300 K, and is detectable by Hyper-CEST NMR at 1.8 pM in PBS and at 1 μM in human plasma where many molecules, including polyamines, can compete with xenon for CB[6] binding.
摘要
缺乏分子对比剂减缓了超灵敏极化（129）氙 NMR 方法的应用。在这里，我们报告说，商业上可获得的葫芦[6]脲（CB[6]）在 300 K 下经历快速氙交换动力学，并且可以在 PBS 中以 1.8 pM 和在人血浆中以 1 μM 的浓度通过 Hyper-CEST NMR 检测到，其中许多分子，包括多胺，可以与氙竞争与 CB[6]结合。
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