Shanxi Eye Hospital, Shanxi, P.R. China.
The First Hospital of Shanxi Medical University, Shanxi, P.R. China.
BMC Ophthalmol. 2015 May 7;15:49. doi: 10.1186/s12886-015-0039-6.
Corneal biometric parameters can possibly be influenced by high myopia (HM). The influence of HM on corneal thickness (CT), epithelial thickness (ET) has not yet been clearly established. The aim of this study is to observe ET, CT and axial length (AL) differences between in normal and subjects with HMs and to investigate factors influencing the corneal biometric parameters and AL, such as age and gender.
A total of 97 normal subjects (97 eyes) and 48 HM subjects (48 eyes) were included. The ET and CT of the central 6-mm diameter (17 regions) and the AL data were captured. The 17 corneal and epithelial regions were the center (1 mm radius, area a), the inner ring (2.5 mm radius, area b), the outer ring (3 mm radius, area c) and the 8 radial scan lines in eight directions (Superior (1) , SN (2), Nasal (3), IN (4), Inferior (5), IT (6), Temporal (7), ST (8)) with an angle of 45° between each consecutive scan line (a, b 1-8, c 1-8).
The ALs were increased about 4 mm in the HMs (P < 0.001). No differences in ET were observed; in contrast, significantly thicker CTs were observed in the HMs in 16 regions except the b5 subregion. In normal group, age was negatively correlated with AL but not CCT and CET and gender was correlated with CET. In HM group, age was not correlated with CCT , AL or CET and gender was correlated with AL and CCT but not CET.
CT was thicker in the HMs but not ET. Age and gender should be considered for AL, CT and ET in both normal and HM group.
角膜生物测量参数可能受高度近视（HM）影响。高度近视对角膜厚度（CT）、上皮厚度（ET）的影响尚未明确。本研究旨在观察正常人群与高度近视人群的 ET、CT 和眼轴（AL）差异，并探讨年龄、性别等因素对角膜生物测量参数和 AL 的影响。
纳入 97 例正常人群（97 眼）和 48 例高度近视人群（48 眼）。获取中央 6mm 直径（17 个区域）的 ET 和 CT 以及 AL 数据。17 个角膜和上皮区域包括中心（1mm 半径，区域 a）、内环（2.5mm 半径，区域 b）、外环（3mm 半径，区域 c）以及 8 条径向扫描线（8 个方向，上（1）、鼻上（2）、鼻侧（3）、鼻下（4）、下（5）、颞上（6）、颞侧（7）、颞下（8）），每条连续扫描线之间的夹角为 45°（a、b1-8、c1-8）。
高度近视人群的 AL 增加约 4mm（P<0.001）。ET 无差异；相反，除 b5 亚区外，高度近视人群的 CT 在 16 个区域明显增厚。在正常组中，年龄与 AL 呈负相关，与 CCT 和 CET 不相关，性别与 CET 相关。在高度近视组中，年龄与 CCT、AL 或 CET 不相关，性别与 AL 和 CCT 相关，但与 CET 不相关。
高度近视人群的 CT 较厚，但 ET 无差异。年龄和性别应考虑纳入正常和高度近视人群的 AL、CT 和 ET 中。
