Institute for Biological Research "Siniša Stanković", University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia.
Food Funct. 2015 Jun;6(6):1900-10. doi: 10.1039/c4fo01135j.
Agaricus bisporus is a cultivated mushroom; A. bitorquis, A. campestris and A. macrosporus are edible mushrooms growing wild in nature. A chemical characterization was carried out with samples that originated in Serbia. Antioxidant, antimicrobial and anti-quorum sensing properties of their methanolic and ethanolic extracts were assessed. A. campestris had the lowest caloric value and total sugar content and showed the highest concentration in organic and phenolic acids, as also in tocopherols (mainly γ-tocopherol). In general, the methanolic extracts showed higher antioxidant, but lower antibacterial and antifungal potential than ethanolic ones. Sub-inhibitory concentrations of the ethanolic extracts demonstrated reduction of virulence factors, AQ inhibition zones, twitching and swimming motility. The biofilm forming capability of P. aeruginosa PAO1 was also reduced in a concentration-dependent manner at sub-MIC values. The extracts of the tested Agaricus species are a promising source of antioxidant, antimicrobial and antiquorum sensing compounds.
双孢蘑菇是一种栽培蘑菇；双孢蘑菇、A. campestris 和 A. macrosporus 是野生可食用蘑菇。对源自塞尔维亚的样本进行了化学特性分析。评估了其甲醇和乙醇提取物的抗氧化、抗菌和抗群体感应特性。A. campestris 的热量值和总糖含量最低，而在有机酸和酚酸以及生育酚（主要是γ-生育酚）中含量最高。一般来说，甲醇提取物的抗氧化能力高于乙醇提取物，但抗菌和抗真菌潜力较低。在亚抑菌浓度下，乙醇提取物可减少毒力因子、抑菌圈、翻滚和泳动运动。在亚最小抑菌浓度下，铜绿假单胞菌 PAO1 的生物膜形成能力也呈浓度依赖性降低。测试的蘑菇品种的提取物是抗氧化剂、抗菌剂和抗群体感应化合物的有前途的来源。
