使用频域Cirrus® HD-OCT和时域Visante® OCT评估泪膜半月板的可重复性。

Repeatability of tear meniscus evaluation using spectral-domain Cirrus® HD-OCT and time-domain Visante® OCT.

作者信息

Chan Hiok Hong, Zhao Yang, Tun Tin A, Tong Louis

机构信息

Singapore National Eye Center, 11 Third Hospital Avenue, Singapore 168751, Singapore.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

出版信息

Cont Lens Anterior Eye. 2015 Oct;38(5):368-72. doi: 10.1016/j.clae.2015.04.002. Epub 2015 May 5.

DOI:10.1016/j.clae.2015.04.002

PMID:25956571

Abstract

PURPOSE

To investigate the intra-rater, inter-rater and inter-device repeatability of a spectral-domain OCT (Cirrus) and a time-domain OCT (Visante) for tear meniscus height (TMH) and area (TMA) measurements.

METHODS

20 participants with no known eye disease were recruited. Both eyes of participants were imaged with both OCTs under the similar conditions. The inferior tear meniscus was imaged at 6 o'clock position whereas the superior meniscus was imaged at 12 o'clock position. Data from the right eyes was analyzed. Two raters independently measured TMH and TMA using the OCT images, and one rater repeated the measurements. Intra-rater, inter-rater and inter-device repeatability of measurements were assessed using Bland-Altman plots and pooled standard deviation.

RESULTS

For intra-rater repeatability, TMH and TMA measurements were more repeatable in Cirrus than Visante (95% limits of agreement (LOA): TMH (μm), -22 to 66 (Cirrus), -125 to 45 (Visante); TMA (μm(2)), -1632 to 5331 (Cirrus), -38,050 to 21,874 (Visante)). For inter-rater agreement, TMH and TMA were also more repeatable in Cirrus than Visante (95%LOA: TMH (μm), -29 to 107 (Cirrus), -215 to 252 (Visante); TMA (μm(2)), -6650 to 9567 (Cirrus), -33,119 to 39,272 (Visante)). Inter-device agreement was poor (95%LOA: TMH (μm), -158 to 150; TMA (μm(2)), -32,903 to 14,076). There was no significant difference in inferior TMH between Cirrus and Visante (p>0.05). Inferior TMA was significantly lower in Cirrus by a mean difference of 10,223μm(2) (95% confidence interval, 5479, 14,966) (p=0.0002).

CONCLUSION

Spectral-domain OCT is superior to time-domain OCT for intra-rater and inter-rater repeatability of TMH and TMA measurements.

摘要

目的

研究光谱域光学相干断层扫描（Cirrus）和时域光学相干断层扫描（Visante）在测量泪液半月板高度（TMH）和面积（TMA）方面的内部评估者、评估者间及设备间的可重复性。

方法

招募20名无已知眼部疾病的参与者。在相似条件下，使用两种光学相干断层扫描对参与者的双眼进行成像。在6点钟位置对下方泪液半月板进行成像，而在12点钟位置对上侧半月板进行成像。分析右眼的数据。两名评估者使用光学相干断层扫描图像独立测量TMH和TMA，一名评估者重复测量。使用Bland-Altman图和合并标准差评估测量的内部评估者、评估者间及设备间的可重复性。

结果

对于内部评估者的可重复性，Cirrus测量TMH和TMA比Visante更具可重复性（95%一致性界限（LOA）：TMH（μm），-22至66（Cirrus），-125至45（Visante）；TMA（μm²）,-1632至5331（Cirrus），-38,050至21,874（Visante））。对于评估者间的一致性，Cirrus测量TMH和TMA也比Visante更具可重复性（95%LOA：TMH（μm），-29至107（Cirrus），-215至252（Visante）；TMA（μm²），-6,650至9,567（Cirrus），-33,119至39,272（Visante））。设备间的一致性较差（95%LOA：TMH（μm），-158至150；TMA（μm²），-32,903至14,076）。Cirrus和Visante之间下方TMH无显著差异（p>0.05）。Cirrus下方TMA显著更低，平均差异为10,223μm²（95%置信区间，5479，14,966）（p = 0.0002）。