核受体在调节Th17/Treg生物学中的作用及其对疾病的影响。
The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases.
作者信息
Park Benjamin V, Pan Fan
出版信息
Cell Mol Immunol. 2015 Sep;12(5):533-42. doi: 10.1038/cmi.2015.21.
Abstract
Nuclear receptors in the cell play essential roles in environmental sensing, differentiation, development, homeostasis,and metabolism and are thus highly conserved across multiple species. The anti-inflammatory role of nuclear receptors in immune cells has recently gained recognition. Nuclear receptors play critical roles in both myeloid and lymphoid cells, particularly in helper CD41 T-cell type 17 (Th17) and regulatory T cells (Treg). Th17 and Treg are closely related cell fates that are determined by orchestrated cytokine signaling. Recent studies have emphasized the interactions between nuclear receptors and the known cytokine signals and how such interaction affects Th17/Treg development and function.This review will focus on the most recent discoveries concerning the roles of nuclear receptors in the context of therapeutic applications in autoimmune diseases.
摘要
细胞中的核受体在环境感知、分化、发育、体内平衡和代谢中发挥着重要作用，因此在多个物种中高度保守。核受体在免疫细胞中的抗炎作用最近得到了认可。核受体在髓系和淋巴细胞中都起着关键作用，特别是在辅助性CD4+T细胞17型（Th17）和调节性T细胞（Treg）中。Th17和Treg是密切相关的细胞命运，由精心编排的细胞因子信号决定。最近的研究强调了核受体与已知细胞因子信号之间的相互作用，以及这种相互作用如何影响Th17/Treg的发育和功能。本综述将聚焦于核受体在自身免疫性疾病治疗应用背景下作用的最新发现。
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本文引用的文献
1
Th17 cells in autoimmune diseases.自身免疫性疾病中的辅助性T细胞17
Front Med. 2015 Mar;9(1):10-9. doi: 10.1007/s11684-015-0388-9. Epub 2015 Feb 4.
2
Vitamin D as a novel therapy in inflammatory bowel disease: new hope or false dawn?维生素 D 作为炎症性肠病的一种新型治疗方法：新希望还是虚假曙光？
Proc Nutr Soc. 2015 Feb;74(1):5-12. doi: 10.1017/S0029665114001621. Epub 2014 Dec 10.
3
NR4A nuclear receptors are orphans but not lonesome.NR4A核受体虽属孤儿受体，但并非形单影只。
Biochim Biophys Acta. 2014 Nov;1843(11):2543-2555. doi: 10.1016/j.bbamcr.2014.06.010. Epub 2014 Jun 27.
4
Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials.维生素 D 与多种健康结局：观察性研究和随机试验的系统评价和荟萃分析的伞状评价。
BMJ. 2014 Apr 1;348:g2035. doi: 10.1136/bmj.g2035.
5
6
The evidence for a beneficial role of vitamin A in multiple sclerosis.维生素A在多发性硬化症中发挥有益作用的证据。
CNS Drugs. 2014 Apr;28(4):291-9. doi: 10.1007/s40263-014-0148-4.
7
Th9 cells, new players in adaptive immunity.Th9 细胞，适应性免疫的新成员。
Trends Immunol. 2014 Feb;35(2):61-8. doi: 10.1016/j.it.2013.10.004. Epub 2013 Nov 8.
8
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.视黄酸 X 受体激动剂通过调节 Foxp3⁺调节性 T 细胞和 Th17 细胞分化，其依赖于视黄酸受体激活的程度存在差异。
J Immunol. 2013 Oct 1;191(7):3725-33. doi: 10.4049/jimmunol.1300032. Epub 2013 Aug 26.
9
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.泛素连接酶 Stub1 通过促进转录因子 Foxp3 的降解来负调控调节性 T 细胞的抑制活性。
Immunity. 2013 Aug 22;39(2):272-85. doi: 10.1016/j.immuni.2013.08.006.
10
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.去泛素化酶 USP7 通过稳定转录因子 Foxp3 增加 Treg 细胞抑制能力。
Immunity. 2013 Aug 22;39(2):259-71. doi: 10.1016/j.immuni.2013.05.018.
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