Uchida K
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University Nagoya , Japan.
Free Radic Res. 2015;49(7):896-904. doi: 10.3109/10715762.2015.1036052. Epub 2015 May 26.
Various lines of evidence indicate that an important part in the pathogenesis of atherosclerosis is the modification of the plasma low-density lipoproteins (LDLs). A large number of pro-inflammatory and pro-atherogenic properties have been ascribed to the oxidatively modified LDLs and their components. There is considerable evidence to support the role of lipid peroxidation products, reactive aldehydes in particular, originating from the oxidized LDL as important signaling molecules in the context of the atherosclerotic lesion. These aldehydes generated during the peroxidation of LDL exhibit a facile reactivity with proteins, generating a variety of intra- and intermolecular covalent adducts on the apolipoprotein B-100 particle in LDL. Characterization of the aldehyde adducts generated in the protein is therefore critical in understanding the nature of the oxidized LDL. However, the majority of adducts generated during the oxidative modification of LDL have not yet been chemically characterized. In this review, the current status of aldehyde adducts quantitatively analyzed in the Cu(2+)-oxidized LDL is reviewed.
多方面的证据表明，血浆低密度脂蛋白（LDL）的修饰在动脉粥样硬化发病机制中起着重要作用。大量促炎和促动脉粥样硬化特性已归因于氧化修饰的LDL及其成分。有相当多的证据支持脂质过氧化产物，特别是活性醛，源自氧化LDL，在动脉粥样硬化病变中作为重要信号分子发挥作用。LDL过氧化过程中产生的这些醛与蛋白质具有易反应性，在LDL中的载脂蛋白B - 100颗粒上产生多种分子内和分子间共价加合物。因此，对蛋白质中产生的醛加合物进行表征对于理解氧化LDL的性质至关重要。然而，LDL氧化修饰过程中产生的大多数加合物尚未进行化学表征。在本综述中，对在Cu(2 +)氧化的LDL中定量分析的醛加合物的现状进行了综述。
