Fu Qing-Ling, Ma Jin-Xiang, Ou Chun-Quan, Guo Cui, Shen Shuang-Quan, Xu Geng, Shi Jianbo
Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Road II, Guangzhou, Guangdong, 510080, China.
Department of Applied Statistics, School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.
PLoS One. 2015 May 15;10(5):e0126881. doi: 10.1371/journal.pone.0126881. eCollection 2015.
Chronic rhinosinusitis (CRS) is a frequently occurring chronic respiratory disease. There is evidence that effective treatment of CRS can improve patients' quality of life, but the data regarding the extent to which CRS impairs patients' quality of life (QoL) is sparse. This study aimed to evaluate the effect of self-reported CRS on health-related QoL and to determine whether the influence was associated with gender, age and socio-economic status. A four-stage random sampling method was used to select the participants from the general population in Guangzhou, China. All participants were interviewed face-to-face at their homes using a standardized questionnaire. The health-related QoL of each participant was assessed using the SF-36 Health Survey. The scores of the SF-36 after adjusting for gender, age, socioeconomic conditions, smoking and some important comorbid conditions were compared between the CRS group and the non-CRS group using analysis of covariance. A multiple linear regression model with interaction terms was established to determine whether CRS affected QoL to the same degree across the different subpopulations. Among a total of 1,411 participants aged at least 15 years, 118 persons (8.4%) had self-reported CRS. Subjects with CRS had an increased prevalence of allergic rhinitis, chronic obstructive pulmonary disease and gout than subjects without CRS. The CRS group had lower scores in all eight domains and the physical and mental component summary than those without CRS (P<0.05), and the greatest differences were in role emotional function (RE), general health (GH) and role physical function (RP). The impairments of the CRS participants in RE and RP were greater among the females than the males. Moreover, physical domains were affected to greater degrees among the elderly and those with high-level education. In conclusion, CRS is a common chronic disorder. Persons with self-reported CRS perceived themselves as having impaired QoL in both the physical and mental domains. These findings shed new light on the health burden of CRS and should be taken into account by clinicians involved in the care of CRS patients.
慢性鼻-鼻窦炎（CRS）是一种常见的慢性呼吸道疾病。有证据表明，有效治疗CRS可改善患者的生活质量，但关于CRS对患者生活质量（QoL）损害程度的数据却很稀少。本研究旨在评估自我报告的CRS对健康相关生活质量的影响，并确定这种影响是否与性别、年龄和社会经济地位相关。采用四阶段随机抽样方法从中国广州的普通人群中选取参与者。所有参与者均在家中接受面对面访谈，使用标准化问卷。使用SF-36健康调查评估每位参与者的健康相关生活质量。采用协方差分析比较CRS组和非CRS组在调整性别、年龄、社会经济状况、吸烟和一些重要合并症后的SF-36得分。建立带有交互项的多元线性回归模型，以确定CRS在不同亚组中对生活质量的影响程度是否相同。在总共1411名年龄至少15岁的参与者中，有118人（8.4%）自我报告患有CRS。与无CRS的受试者相比，患有CRS的受试者患过敏性鼻炎、慢性阻塞性肺疾病和痛风的患病率更高。CRS组在所有八个领域以及身体和心理综合得分方面均低于无CRS组（P<0.05），最大差异在于角色情感功能（RE）、总体健康（GH）和角色身体功能（RP）。CRS参与者在RE和RP方面的损害在女性中比男性更大。此外，身体领域在老年人和高学历人群中受影响程度更大。总之，CRS是一种常见的慢性疾病。自我报告患有CRS的人认为自己在身体和心理领域的生活质量均受损。这些发现为CRS的健康负担提供了新的线索，参与CRS患者护理的临床医生应予以考虑。
