Pompili Cecilia
Division of Thoracic Surgery, St. James' University Hospital, Leeds, UK.
J Thorac Dis. 2015 Apr;7(Suppl 2):S138-44. doi: 10.3978/j.issn.2072-1439.2015.04.40.
Radical and palliative treatments for non-small cell lung cancer (NSCLC) have been reported to have a significant impact on the patient quality of life (QoL). The increasing improvements in lung cancer diagnosis and cures in recent years have changed the perspectives of quantity and quality of the life after cancer in these patients. However, despite a growing interest about patient reported outcome measures (PROMs) in surgical oncology, we are quite distant from a routine collection of QoL data after pulmonary resection for NSCLC. The presence of this gap is due to several reasons: the lack of validated surgical-specific questionnaires, the inappropriate consideration of traditional objective parameters as surrogates of QoL outcomes and the difficulties in dealing with missing items in this type of research. However, a recent the European Society of Thoracic Surgeons (ESTS) survey exploring the use of QoL data in our field has revealed that almost half of the units responding to the questionnaire collect QoL informations from their patients. Increased consensus and collaboration between surgeons are needed to include routinely PROMs in randomized controlled trials. The objective of this paper is to review the best available evidence published in the literature and regarding QoL after lung resection for cancer, aiming at identifying topics deserving further investigations.
据报道,非小细胞肺癌(NSCLC)的根治性和姑息性治疗对患者生活质量(QoL)有重大影响。近年来肺癌诊断和治疗方法的不断改进,改变了这些患者癌症后生活的数量和质量观念。然而,尽管外科肿瘤学领域对患者报告结局指标(PROMs)的兴趣日益浓厚,但我们距离NSCLC肺切除术后生活质量数据的常规收集仍有很大差距。存在这一差距的原因有几个:缺乏经过验证的手术专用问卷,将传统客观参数不恰当地视为生活质量结果的替代指标,以及在这类研究中处理缺失项目的困难。然而,欧洲胸外科医师协会(ESTS)最近一项关于在我们这个领域使用生活质量数据的调查显示,回复问卷的单位中几乎有一半从患者那里收集生活质量信息。需要外科医生之间加强共识与合作,以便在随机对照试验中常规纳入患者报告结局指标。本文的目的是回顾文献中已发表的关于肺癌肺切除术后生活质量的最佳现有证据,旨在确定值得进一步研究的主题。