Singh Harpal, Shimojima Masayuki, Ngoc Thanh Cao, Quoc Huy Nguyen Vu, Chuong Tran Xuan, Le Van An, Saijo Masayuki, Yang Ming, Sugamata Masami
Department of Intelligent Mechanical Systems, Graduate School of System Design, Tokyo Metropolitan University, Tokyo, Japan.
Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
J Med Virol. 2015 Dec;87(12):2145-8. doi: 10.1002/jmv.24274. Epub 2015 Jun 2.
Pteropine orthoreovirus, potentially of bat origin, has been reported to cause respiratory tract infections among human beings in Southeast Asia. Twelve IgG ELISA-positive cases with antibodies against Pteropine orthoreovirus were detected among 272 human serum samples collected between March and June 2014 from in and around Hue City, Central Vietnam. These 12 cases were IgM ELISA negative. Neutralizing antibodies were also detected among six of these cases with the highest titer of 1:1,280 in 2 cases (both female, 32 and 68 years old, respectively). This is the first report of human infection with Pteropine orthoreovirus in Central Vietnam. These findings indicate the need for surveillance on Pteropine orthoreovirus infections in Southeast Asia to enable prevention and control strategies to be developed should a change in virulence occur.
翼手目正呼肠孤病毒可能源自蝙蝠，据报道在东南亚可导致人类呼吸道感染。2014年3月至6月期间从越南中部顺化市及其周边地区采集的272份人类血清样本中，检测出12例针对翼手目正呼肠孤病毒的IgG酶联免疫吸附测定呈阳性。这12例病例的IgM酶联免疫吸附测定均为阴性。其中6例还检测到中和抗体，2例中和抗体效价最高，达1:1280（分别为32岁和68岁女性）。这是越南中部人类感染翼手目正呼肠孤病毒的首例报告。这些发现表明，有必要对东南亚的翼手目正呼肠孤病毒感染进行监测，以便在病毒毒力发生变化时制定预防和控制策略。
