Camara Soriba Naby, Ramdany Sonam, Zhao Gang, Gou Shan-Miao, Xiong Jiong-Xin, Yang Zhi-Yong, Yin Tao, Yang Ming, Balde Oumar Taibata, Barry Ahmed Boubacar, Adji Seid, Li Xiang, Jin Yan, Wu He-Shui, Wang Chun-You
Department of General Surgery, Pancreatic Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of General Surgery, National Hospital of Donka, Conakry, Guinea.
J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):384-389. doi: 10.1007/s11596-015-1442-1. Epub 2015 Jun 14.
The purpose of this study was to investigate the etiology, pathological characteristics, management and prognosis of chronic pancreatitis in the Chinese population. The clinical data of 142 patients with chronic pancreatitis were retrospectively studied. All patients were of Chinese nationality and hospitalized from January 2008 to December 2011. Their ages ranged from 14 to 76 years, with a mean of 43 years. Of 142 patients, there were 72 cases of obstructive chronic pancreatitis (50.70%), 19 cases of alcoholic chronic pancreatitis (13.38%), 14 cases of autoimmune pancreatitis (9.86%) and 37 cases of undetermined etiology (26.06%). Pathologically, the average inflammatory mass diameter was 3.8 ± 3.3 cm, biliary obstruction occurred in 36 cases, gall stones in 70 cases, calcification in 88 cases, ductal dilatation in 61 cases, side branch dilatation in 32 cases, ductal irregularity in 10 cases, lymphocytic inflammation in 23 cases, obliterative phlebitis in 14 cases, extra pancreatic lesion in 19 cases and fibrosis in 142 cases. Location of pancreatic lesion in the region of head (n=97), neck (n=16), body (n=12), tail (n=15) and whole pancreas (n=2) influenced the choice of surgical procedures. Ninety-four patients (66.20%) received surgical treatment and 33.80% received other treatments. After operation, 80.85% of 94 patients experienced decreased pain, and 8.51% of 94 showed recovery of endocrine function but with a complication rate of 12.77%. All the operations were performed successfully. According to the pain scale of European Organization for Research and Treatment of Cancer (QLQ-C30) a decrease from 76 ± 22 to 14 ± 18 was observed. Etiology, pathological characteristics, management and prognosis of chronic pancreatitis in the Chinese population vary from others.
本研究旨在探讨中国人群慢性胰腺炎的病因、病理特征、治疗方法及预后。对142例慢性胰腺炎患者的临床资料进行回顾性研究。所有患者均为中国国籍，于2008年1月至2011年12月住院。年龄范围为14至76岁，平均年龄43岁。142例患者中，梗阻性慢性胰腺炎72例（50.70%），酒精性慢性胰腺炎19例（13.38%），自身免疫性胰腺炎14例（9.86%），病因不明37例（26.06%）。病理检查显示，炎性肿块平均直径为3.8±3.3 cm，胆管梗阻36例，胆结石70例，钙化88例，导管扩张61例，分支扩张32例，导管不规则10例，淋巴细胞炎症23例，闭塞性静脉炎14例，胰腺外病变19例，纤维化142例。胰腺病变位于胰头（n=97）、胰颈（n=16）、胰体（n=12）、胰尾（n=15）及全胰腺（n=2）的部位影响手术方式的选择。94例（66.20%）患者接受了手术治疗，33.80%接受了其他治疗。术后，94例患者中有80.85%疼痛减轻，94例中有8.51%内分泌功能恢复，但并发症发生率为12.77%。所有手术均成功完成。根据欧洲癌症研究与治疗组织（QLQ-C30）疼痛量表，疼痛评分从76±22降至14±18。中国人群慢性胰腺炎的病因、病理特征、治疗方法及预后与其他人群不同。
