Robbins Jeremy, Petrone Andrew B, Gaziano J Michael, Djoussé Luc
Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology and Research Information Center and Geriatric Research, Education, and Clinical Center, Boston Veterans Affairs Healthcare System, Boston, MA, USA.
Division of Aging, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Clin Nutr. 2016 Jun;35(3):650-3. doi: 10.1016/j.clnu.2015.04.011. Epub 2015 Apr 22.
Experimental studies have demonstrated the role of vitamin D in key pathways related to cardiovascular health. While several studies have investigated the impact of vitamin D therapy on outcomes in subjects with prevalent heart failure, limited research exists on the relationship of dietary vitamin D consumption with the risk of heart failure. Thus, we sought to investigate whether dietary vitamin D consumption was associated with a lower risk of incident heart failure in a large prospective cohort of male physicians.
We prospectively studied 19,635 males from the Physicians' Health Study. Dietary vitamin D information was obtained from a baseline food frequency questionnaire, and heart failure information was obtained by questionnaire and validated in a subsample. Mean age was 66.4 years. Median dietary vitamin D consumption was 200.4 IU and only 2.3% of the subjects used vitamin D supplements. After an average follow-up of 9.3 years, there were 858 new cases of heart failure identified. Higher intake of dietary vitamin D was not associated with incident heart failure in a multivariable adjusted model: hazard ratios (95% CI) of incident heart failure were 1.0 (reference), 1.29 (1.04-1.60), 1.17 (0.94-1.46), 1.22 (0.98-1.53), and 1.16 (0.92-1.46) from lowest to highest age- and energy-adjusted vitamin D quintile, respectively, after adjusting for age, BMI, race, exercise, alcohol use, smoking, calories, and prevalent atrial fibrillation (p for linear trend = 0.64).
These data are consistent with a lack of an association between dietary vitamin D and incident heart failure in this population of professionally-employed middle-aged males.
实验研究已证明维生素D在与心血管健康相关的关键途径中的作用。虽然有几项研究调查了维生素D治疗对患有心力衰竭的受试者结局的影响，但关于饮食中维生素D摄入量与心力衰竭风险之间的关系的研究有限。因此，我们试图在一大群男性医生的前瞻性队列中调查饮食中维生素D的摄入量是否与较低的心力衰竭发病风险相关。
我们对来自医生健康研究的19635名男性进行了前瞻性研究。饮食中维生素D的信息来自基线食物频率问卷，心力衰竭信息通过问卷获得并在一个子样本中得到验证。平均年龄为66.4岁。饮食中维生素D的摄入量中位数为200.4国际单位，只有2.3%的受试者使用维生素D补充剂。在平均随访9.3年后，共确定了858例新的心力衰竭病例。在多变量调整模型中，饮食中维生素D摄入量较高与心力衰竭发病无关：从最低到最高年龄和能量调整后的维生素D五分位数，心力衰竭发病的风险比（95%可信区间）分别为1.0（参考值）、1.29（1.04 - 1.60）、1.17（0.94 - 1.46）、1.22（0.98 - 1.53）和1.16（0.92 - 1.46），在调整了年龄、体重指数、种族、运动、饮酒、吸烟、卡路里和房颤患病率后（线性趋势p = 0.64）。
这些数据与该职业中年男性人群中饮食中维生素D与心力衰竭发病之间缺乏关联一致。
