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探寻成体神经发生的根源

Finding the Roots of Adult Neurogenesis.

作者信息

Kheirbek Mazen A

机构信息

Department of Psychiatry, Columbia University, New York, NY 10032, USA; Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY 10032, USA.

出版信息

Cell. 2015 Jun 18;161(7):1500-2. doi: 10.1016/j.cell.2015.06.010.

DOI:10.1016/j.cell.2015.06.010
PMID:26091033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5771261/
Abstract

In select areas of the brain, neural stem cells produce new neurons throughout life. An elegant new study in this issue of Cell reveals the origins of a stem cell population that persists into adulthood and uncovers a surprising relationship between neurons born in the mature brain and those generated early in development.

摘要

在大脑的特定区域，神经干细胞在整个生命过程中都会产生新的神经元。本期《细胞》杂志上一项出色的新研究揭示了一个持续到成年期的干细胞群体的起源，并发现了成熟大脑中产生的神经元与发育早期产生的神经元之间令人惊讶的关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d28/5771261/972c26349a24/nihms930858f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d28/5771261/972c26349a24/nihms930858f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d28/5771261/972c26349a24/nihms930858f1.jpg

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本文引用的文献

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Embryonic Origin of Postnatal Neural Stem Cells.产后神经干细胞的胚胎起源
Cell. 2015 Jun 18;161(7):1644-55. doi: 10.1016/j.cell.2015.05.041.
2
Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone.成年室管膜下区的快速克隆扩增和有限的神经干细胞自我更新。
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The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus.腹侧海马是齿状回内成年神经干细胞的胚胎起源。
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Radial glia give rise to adult neural stem cells in the subventricular zone.放射状胶质细胞可产生脑室下区的成体神经干细胞。
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.脑室下区星形胶质细胞是成年哺乳动物大脑中的神经干细胞。
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