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学习中的个体差异预示着恐惧的复发。

Individual differences in learning predict the return of fear.

作者信息

Gershman Samuel J, Hartley Catherine A

机构信息

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA,

出版信息

Learn Behav. 2015 Sep;43(3):243-50. doi: 10.3758/s13420-015-0176-z.

Abstract

Using a laboratory analogue of learned fear (Pavlovian fear conditioning), we show that there is substantial heterogeneity across individuals in spontaneous recovery of fear following extinction training. We propose that this heterogeneity might stem from qualitative individual differences in the nature of extinction learning. Whereas some individuals tend to form a new memory during extinction, leaving their fear memory intact, others update the original threat association with new safety information, effectively unlearning the fear memory. We formalize this account in a computational model of fear learning and show that individuals who, according to the model, are more likely to form new extinction memories tend to show greater spontaneous recovery compared to individuals who appear to only update a single memory. This qualitative variation in fear and extinction learning may have important implications for understanding vulnerability and resilience to fear-related psychiatric disorders.

摘要

利用习得性恐惧的实验室模拟情境(巴甫洛夫恐惧条件反射),我们发现,在消退训练后恐惧的自发恢复方面,个体之间存在显著的异质性。我们提出,这种异质性可能源于消退学习本质上的个体质性差异。一些个体在消退过程中倾向于形成新记忆,使他们的恐惧记忆保持完整,而另一些个体则用新的安全信息更新原始的威胁关联,从而有效地消除恐惧记忆。我们在一个恐惧学习的计算模型中对这一观点进行了形式化表述,并表明,根据该模型,相较于那些似乎只更新单一记忆的个体,更有可能形成新消退记忆的个体往往表现出更大程度的自发恢复。恐惧和消退学习中的这种质性差异,可能对理解与恐惧相关的精神疾病的易感性和恢复力具有重要意义。

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