经设计可攻击细菌的无机纳米颗粒。
Inorganic nanoparticles engineered to attack bacteria.
机构信息
Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA.
Department of Chemistry and Biochemistry, College of Arts and Sciences, University of South Carolina, Columbia, South Carolina 29208, USA.
出版信息
Chem Soc Rev. 2015 Nov 7;44(21):7787-807. doi: 10.1039/c5cs00041f.
Antibiotics were once the golden bullet to constrain infectious bacteria. However, the rapid and continuing emergence of antibiotic resistance (AR) among infectious microbial pathogens has questioned the future utility of antibiotics. This dilemma has recently fueled the marriage of the disparate fields of nanochemistry and antibiotics. Nanoparticles and other types of nanomaterials have been extensively developed for drug delivery to eukaryotic cells. However, bacteria have very different cellular architectures than eukaryotic cells. This review addresses the chemistry of nanoparticle-based antibiotic carriers, and how their technical capabilities are now being re-engineered to attack, kill, but also non-lethally manipulate the physiologies of bacteria. This review also discusses the surface functionalization of inorganic nanoparticles with small ligand molecules, polymers, and charged moieties to achieve drug loading and controllable release.
抗生素曾经是限制感染性细菌的“金弹丸”。然而，感染性微生物病原体中抗生素耐药性（AR）的迅速和持续出现，对抗生素的未来应用提出了质疑。这种困境最近促使纳米化学和抗生素这两个截然不同的领域联姻。已经广泛开发了纳米粒子和其他类型的纳米材料用于向真核细胞输送药物。然而，细菌的细胞结构与真核细胞有很大的不同。本综述介绍了基于纳米粒子的抗生素载体的化学性质，以及它们的技术能力如何正在被重新设计以攻击、杀死，而且还能非致死性地操纵细菌的生理机能。本综述还讨论了用小分子配体、聚合物和带电基团对无机纳米粒子进行表面功能化，以实现药物负载和可控释放。
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