献血者中的无症状麻风感染可能预示疾病发展并提示一种潜在传播方式。
Asymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission.
作者信息
Goulart Isabela Maria Bernardes, Araujo Sergio, Filho Adilson Botelho, de Paiva Paulo Henrique Ribeiro, Goulart Luiz Ricardo
机构信息
National Reference Center for Sanitary Dermatology and Leprosy, Clinics Hospital, Federal University of Uberlandia, Minas Gerais, Brazil Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlandia, Minas Gerais, Brazil.
National Reference Center for Sanitary Dermatology and Leprosy, Clinics Hospital, Federal University of Uberlandia, Minas Gerais, Brazil Postgraduate Program in Health Sciences, School of Medicine, Federal University of Uberlandia, Minas Gerais, Brazil
出版信息
J Clin Microbiol. 2015 Oct;53(10):3345-8. doi: 10.1128/JCM.01305-15. Epub 2015 Jul 22.
Abstract
Blood donor samples (1,007) were assessed for anti-phenolic glycolipid 1 (PGL-1) IgM antibodies and Mycobacterium leprae DNA presence, which had 3.8% and 0.3% positivity, respectively. After a 5-year follow-up period, six individuals with positive markers developed leprosy, raising the hypothesis that asymptomatic infection among blood donors may be an undisclosed mode of leprosy transmission via transfusion.
摘要
对1007份献血者样本进行了抗酚糖脂1（PGL-1）IgM抗体和麻风分枝杆菌DNA检测，阳性率分别为3.8%和0.3%。经过5年的随访期，6名标记阳性的个体患上了麻风病，这引发了一种假设，即献血者中的无症状感染可能是麻风病通过输血传播的一种未被发现的方式。
相似文献
1
Asymptomatic Leprosy Infection among Blood Donors May Predict Disease Development and Suggests a Potential Mode of Transmission.献血者中的无症状麻风感染可能预示疾病发展并提示一种潜在传播方式。
J Clin Microbiol. 2015 Oct;53(10):3345-8. doi: 10.1128/JCM.01305-15. Epub 2015 Jul 22.
2
Molecular Evidence for the Aerial Route of Infection of Mycobacterium leprae and the Role of Asymptomatic Carriers in the Persistence of Leprosy.分子证据表明麻风分枝杆菌可通过空气途径感染，无症状携带者在麻风病的持续存在中起作用。
Clin Infect Dis. 2016 Dec 1;63(11):1412-1420. doi: 10.1093/cid/ciw570. Epub 2016 Aug 23.
3
Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia.哥伦比亚麻风病患者家庭接触者中麻风分枝杆菌传播的评估与监测
PLoS Negl Trop Dis. 2017 Jan 23;11(1):e0005325. doi: 10.1371/journal.pntd.0005325. eCollection 2017 Jan.
4
Oral mucosa as a source of Mycobacterium leprae infection and transmission, and implications of bacterial DNA detection and the immunological status.口腔黏膜作为麻风分枝杆菌感染和传播的源头，以及细菌 DNA 检测和免疫状态的意义。
Clin Microbiol Infect. 2011 Nov;17(11):1653-8. doi: 10.1111/j.1469-0691.2010.03453.x. Epub 2011 Mar 3.
5
Anti-PGL1 salivary IgA/IgM, serum IgG/IgM, and nasal Mycobacterium leprae DNA in individuals with household contact with leprosy.与麻风病患者有家庭接触者的抗 PGL1 唾液 IgA/IgM、血清 IgG/IgM 和鼻分枝杆菌 DNA。
Int J Infect Dis. 2013 Nov;17(11):e1005-10. doi: 10.1016/j.ijid.2013.05.011. Epub 2013 Jul 16.
6
Serum IgA1 and IgM antibodies against Mycobacterium leprae-derived phenolic glycolipid-I: a comparative study in leprosy patients and their contacts.血清中抗麻风分枝杆菌衍生酚糖脂-I的IgA1和IgM抗体：麻风病患者及其接触者的比较研究。
Int J Lepr Other Mycobact Dis. 1991 Sep;59(3):441-9.
7
Unveiling healthy carriers and subclinical infections among household contacts of leprosy patients who play potential roles in the disease chain of transmission.揭示麻风病患者家庭接触者中的健康携带者和亚临床感染，这些人在疾病传播链中可能扮演着重要角色。
Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:55-9. doi: 10.1590/s0074-02762012000900010.
8
Detection of anti-M. leprae antibodies in children in leprosy-endemic areas: A systematic review.麻风病流行地区儿童抗麻风分枝杆菌抗体检测：系统评价。
PLoS Negl Trop Dis. 2021 Aug 27;15(8):e0009667. doi: 10.1371/journal.pntd.0009667. eCollection 2021 Aug.
9
10
Production and characterization of peptide mimotopes of phenolic glycolipid-I of Mycobacterium leprae.麻风分枝杆菌酚糖脂-I肽模拟表位的产生与特性分析
FEMS Immunol Med Microbiol. 2004 May 1;41(1):51-7. doi: 10.1016/j.femsim.2004.01.001.
引用本文的文献
1
Leprosy in blood donors.献血者中的麻风病。
Trop Med Int Health. 2025 Sep;30(9):1018-1022. doi: 10.1111/tmi.70007. Epub 2025 Jul 3.
2
qPCR detection of DNA in urine samples of leprosy patients using the gene target.使用该基因靶点对麻风病患者尿液样本中的DNA进行qPCR检测。
Front Mol Biosci. 2024 Aug 13;11:1435679. doi: 10.3389/fmolb.2024.1435679. eCollection 2024.
3
Role of multisegmental nerve ultrasound in the diagnosis of leprosy neuropathy.多节段神经超声在麻风病周围神经病诊断中的作用。
PLoS One. 2024 Jul 18;19(7):e0305808. doi: 10.1371/journal.pone.0305808. eCollection 2024.
4
High-resolution ultrasonography for early diagnosis of neural impairment in seropositive leprosy household contacts.高分辨率超声在早期诊断血清阳性麻风病家庭接触者神经损害中的应用。
PLoS One. 2023 May 23;18(5):e0285450. doi: 10.1371/journal.pone.0285450. eCollection 2023.
5
Early diagnosis of neural impairment in seropositive leprosy household contacts: The experience of a reference center in Brazil.麻风血清学阳性家庭接触者神经损伤的早期诊断：巴西一家参考中心的经验。
Front Med (Lausanne). 2023 Mar 13;10:1143402. doi: 10.3389/fmed.2023.1143402. eCollection 2023.
6
A 5-year evaluation of chemoprophylactic treatment in elementary school children with subclinical leprosy.对亚临床型麻风病小学生进行化学预防治疗的5年评估。
Biomed Rep. 2021 Nov;15(5):88. doi: 10.3892/br.2021.1464. Epub 2021 Aug 24.
7
Latent leprosy infection identified by dual RLEP and anti-PGL-I positivity: Implications for new control strategies.双重 RLEP 和抗 PGL-I 阳性鉴定潜伏性麻风感染：对新控制策略的影响。
PLoS One. 2021 May 13;16(5):e0251631. doi: 10.1371/journal.pone.0251631. eCollection 2021.
8
Cutaneous Mycobacterial Infections.皮肤分枝杆菌感染。
Clin Microbiol Rev. 2018 Nov 14;32(1). doi: 10.1128/CMR.00069-18. Print 2018 Jan.
9
Molecular, immunological and neurophysiological evaluations for early diagnosis of neural impairment in seropositive leprosy household contacts.用于早期诊断血清阳性麻风病家庭接触者神经损伤的分子、免疫和神经生理学评估。
PLoS Negl Trop Dis. 2018 May 21;12(5):e0006494. doi: 10.1371/journal.pntd.0006494. eCollection 2018 May.
10
High frequency of M. leprae DNA detection in asymptomatic household contacts.在无症状的家庭接触者中频繁检测到麻风分枝杆菌 DNA。
BMC Infect Dis. 2018 Apr 2;18(1):153. doi: 10.1186/s12879-018-3056-2.
本文引用的文献
1
Global leprosy update, 2013; reducing disease burden.2013年全球麻风病最新情况；减轻疾病负担
Wkly Epidemiol Rec. 2014 Sep 5;89(36):389-400.
2
Blood discard rate and the prevalence of infectious and contagious diseases in blood donors from provincial towns of the state of Paraná, Brazil.巴西巴拉那州州府城镇献血者的血液废弃率以及传染病和感染性疾病的流行情况。
Rev Bras Hematol Hemoter. 2013;35(6):395-9. doi: 10.5581/1516-8484.20130126.
3
Mycobacterium leprae DNA in peripheral blood may indicate a bacilli migration route and high-risk for leprosy onset.麻风分枝杆菌 DNA 在外周血中可能表明细菌迁移途径和麻风发病的高风险。
Clin Microbiol Infect. 2014 May;20(5):447-52. doi: 10.1111/1469-0691.12349. Epub 2013 Aug 28.
4
Whole-blood nested-PCR amplification of M. leprae-specific DNA for early diagnosis of leprosy.应用全血套式 PCR 扩增麻风分枝杆菌特异性 DNA 进行麻风病的早期诊断。
Am J Trop Med Hyg. 2013 May;88(5):918-22. doi: 10.4269/ajtmh.11-0253. Epub 2013 Mar 11.
5
Unveiling healthy carriers and subclinical infections among household contacts of leprosy patients who play potential roles in the disease chain of transmission.揭示麻风病患者家庭接触者中的健康携带者和亚临床感染，这些人在疾病传播链中可能扮演着重要角色。
Mem Inst Oswaldo Cruz. 2012 Dec;107 Suppl 1:55-9. doi: 10.1590/s0074-02762012000900010.
6
Comparison of three immunological tests for leprosy diagnosis and detection of subclinical infection.三种用于麻风病诊断和亚临床感染检测的免疫学检测方法的比较。
Lepr Rev. 2011 Dec;82(4):389-401.
7
Lepromatous leprosy in a kidney transplant recipient: a case report.肾移植受者中的瘤型麻风：一例报告
Exp Clin Transplant. 2011 Jun;9(3):203-6.
8
Leprosy in transplant recipients: report of a case after liver transplantation and review of the literature.移植受者中的麻风病：1例肝移植后病例报告及文献复习
Transpl Infect Dis. 2011 Feb;13(1):63-9. doi: 10.1111/j.1399-3062.2010.00549.x.
9
Leprosy in a renal transplant recipient: review of the literature.肾移植受者中的麻风病：文献综述
Transpl Infect Dis. 2009 Dec;11(6):557-62. doi: 10.1111/j.1399-3062.2009.00428.x. Epub 2009 Jul 28.
10
Enumeration of Mycobacterium leprae using real-time PCR.实时聚合酶链反应检测麻风分枝杆菌。
PLoS Negl Trop Dis. 2008;2(11):e328. doi: 10.1371/journal.pntd.0000328. Epub 2008 Nov 4.
Zotero 插件