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四种微小RNA的多态性与口腔鳞状细胞癌风险：一项荟萃分析。

Polymorphisms in four microRNAs and risk of oral squamous cell cancer: a meta-analysis.

作者信息

Zeng Junfeng, Yi Xiaowei, Liu Hao, Yang Yi, Duan Yuchen, Chen Hua

机构信息

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu,610041, China.

出版信息

Oncotarget. 2018 Jan 12;9(9):8695-8705. doi: 10.18632/oncotarget.24211. eCollection 2018 Feb 2.

DOI:10.18632/oncotarget.24211
PMID:29492228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5823596/
Abstract

OBJECTIVES

Single nucleotide polymorphisms in microRNAs (microRNA-196a2 rs11614913, microRNA-146a rs2910164, microRNA-149 rs2292832 and microRNA-499 rs3746444) have been inconsistently associated with risk for oral squamous cell cancer (OSCC). This meta-analysis aimed to assess the correlation between microRNA polymorphisms and susceptibility to OSCC.

MATERIALS AND METHODS

Free words were used to search for the relevant studies without language limitations in electronic databases including PubMed, Embase, Web of Science and SCOPUS through June 15, 2017. Odds ratios (ORs) were calculated to investigate the effects of microRNA polymorphisms on oral cancer risk.

RESULTS

Eleven studies were included. Analysis under the recessive model of microRNA-146a (CC vs GG+CG) showed significant differences (ORs = 0.874, P = 0.041). The G allele and the GG genotype of microRNA-499 were associated with OSCC risk (ORs >1, < 0.05). MicroRNA-196a2 rs11614913 and microRNA-149 polymorphisms appeared to have no relationship with OSCC risk ( > 0.05). In the sensitivity analysis, there was a significant association between the TT genotype of microRNA-196a2 and OSCC risk (TT vs TC + CC, ORs < 1, < 0.05).

CONCLUSIONS

There may be no significant relationship between microRNA-149 polymorphisms and OSCC risk, and the CC genotype of microRNA-146a may have protective effects against oral cancer. However, the G allele and the GG genotype of microRNA-499 may increase OSCC risk.

摘要

目的

微小RNA中的单核苷酸多态性（微小RNA - 196a2 rs11614913、微小RNA - 146a rs2910164、微小RNA - 149 rs2292832和微小RNA - 499 rs3746444）与口腔鳞状细胞癌（OSCC）风险的相关性并不一致。本荟萃分析旨在评估微小RNA多态性与OSCC易感性之间的相关性。

材料与方法

截至2017年6月15日，使用自由词在包括PubMed、Embase、科学网和Scopus在内的电子数据库中搜索相关研究，无语言限制。计算优势比（OR）以研究微小RNA多态性对口腔癌风险的影响。

结果

纳入11项研究。在微小RNA - 146a的隐性模型（CC与GG + CG）下进行分析显示存在显著差异（OR = 0.874，P = 0.041）。微小RNA - 499的G等位基因和GG基因型与OSCC风险相关（OR >1，< 0.05）。微小RNA - 196a2 rs11614913和微小RNA - 149多态性似乎与OSCC风险无关（> 0.05）。在敏感性分析中，微小RNA - 196a2的TT基因型与OSCC风险之间存在显著关联（TT与TC + CC，OR < 1，< 0.05）。

结论

微小RNA - 149多态性与OSCC风险之间可能无显著关系，微小RNA - 146a的CC基因型可能对口腔癌具有保护作用。然而，微小RNA - 499的G等位基因和GG基因型可能增加OSCC风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/7986a45d8aaa/oncotarget-09-8695-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/21250f3adeb5/oncotarget-09-8695-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/327002f4dc65/oncotarget-09-8695-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/7e8d8a6defb1/oncotarget-09-8695-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/1578c379ab0e/oncotarget-09-8695-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/7986a45d8aaa/oncotarget-09-8695-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/21250f3adeb5/oncotarget-09-8695-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/327002f4dc65/oncotarget-09-8695-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/7e8d8a6defb1/oncotarget-09-8695-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/1578c379ab0e/oncotarget-09-8695-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e340/5823596/7986a45d8aaa/oncotarget-09-8695-g005.jpg

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