The effect of caffeine and albuterol on body composition and metabolic rate.
作者信息
Liu Ann G, Arceneaux Kenneth P, Chu Jessica T, Jacob Gregory, Schreiber Allyson L, Tipton Russell C, Yu Ying, Johnson William D, Greenway Frank L, Primeaux Stefany D
机构信息
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA.
出版信息
Obesity (Silver Spring). 2015 Sep;23(9):1830-5. doi: 10.1002/oby.21163. Epub 2015 Aug 4.
OBJECTIVE
Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.
METHODS
In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.
RESULTS
Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer-term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain concurrent with decreased fat mass gain with caffeine/albuterol treatment that was greater than albuterol treatment alone.
CONCLUSIONS
In rats, albuterol with caffeine produced significantly greater increases in lean body mass and reductions in fat mass without changes in food intake after 4-8 weeks of treatment. Since caffeine and albuterol are approved for the treatment of asthma in children and adolescents at the doses tested and change body composition without changing food intake, this combination may deserve further exploration for use in treating pediatric obesity.
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