咖啡因和沙丁胺醇对身体成分及代谢率的影响。
The effect of caffeine and albuterol on body composition and metabolic rate.
作者信息
Liu Ann G, Arceneaux Kenneth P, Chu Jessica T, Jacob Gregory, Schreiber Allyson L, Tipton Russell C, Yu Ying, Johnson William D, Greenway Frank L, Primeaux Stefany D
机构信息
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA.
出版信息
Obesity (Silver Spring). 2015 Sep;23(9):1830-5. doi: 10.1002/oby.21163. Epub 2015 Aug 4.
OBJECTIVE
Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.
METHODS
In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.
RESULTS
Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer-term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain concurrent with decreased fat mass gain with caffeine/albuterol treatment that was greater than albuterol treatment alone.
CONCLUSIONS
In rats, albuterol with caffeine produced significantly greater increases in lean body mass and reductions in fat mass without changes in food intake after 4-8 weeks of treatment. Since caffeine and albuterol are approved for the treatment of asthma in children and adolescents at the doses tested and change body composition without changing food intake, this combination may deserve further exploration for use in treating pediatric obesity.
目的
在麻黄碱因安全问题退出市场之前，咖啡因与麻黄碱是一种有效的减肥联合疗法。本研究调查了咖啡因与沙丁胺醇的组合，作为一种可能更安全的麻黄碱替代品。
方法
在一系列使用培养的脂肪细胞、大鼠模型和人类的实验中，评估了咖啡因和沙丁胺醇对脂肪分解、代谢率、食物摄入量和身体成分的影响。
结果
咖啡因和沙丁胺醇均增强了培养脂肪细胞中的脂肪分解。对人类进行咖啡因和/或沙丁胺醇的急性治疗可提高静息代谢率。对大鼠进行的长期研究显示，使用沙丁胺醇治疗有代谢率增加的趋势。咖啡因/沙丁胺醇治疗使瘦体重增加，同时脂肪量增加减少，这比单独使用沙丁胺醇治疗更明显。
结论
在大鼠中，咖啡因与沙丁胺醇联合使用在治疗4至8周后，可显著增加瘦体重并减少脂肪量，且食物摄入量无变化。由于在测试剂量下，咖啡因和沙丁胺醇已被批准用于治疗儿童和青少年哮喘，并且能改变身体成分而不改变食物摄入量，因此这种组合可能值得进一步探索用于治疗儿童肥胖症。
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