电子烟烟雾中的高活性自由基。
Highly reactive free radicals in electronic cigarette aerosols.
作者信息
Goel Reema, Durand Erwann, Trushin Neil, Prokopczyk Bogdan, Foulds Jonathan, Elias Ryan J, Richie John P
机构信息
Department of Public Health Sciences, Pennsylvania State University Tobacco Center for Regulatory Science (TCORS), Pennsylvania State University College of Medicine , Hershey Pennsylvania 17033, United States.
Department of Food Science, College of Agricultural Sciences, Pennsylvania State University , University Park, Pennsylvania 16802, United States.
出版信息
Chem Res Toxicol. 2015 Sep 21;28(9):1675-7. doi: 10.1021/acs.chemrestox.5b00220. Epub 2015 Aug 7.
Abstract
Electronic cigarette (EC) usage has increased exponentially, but limited data are available on its potential harmful effects. We tested for the presence of reactive, short-lived free radicals in EC aerosols by electron paramagnetic resonance spectroscopy (EPR) using the spin-trap phenyl-N-tert-butylnitrone (PBN). Radicals were detected in aerosols from all ECs and eliquids tested (2.5 × 10(13) to 10.3 × 10(13) radicals per puff at 3.3 V) and from eliquid solvents propylene glycol and glycerol and from "dry puffing". These results demonstrate, for the first time, the production of highly oxidizing free radicals from ECs which may present a potential toxicological risk to EC users.
摘要
电子烟（EC）的使用呈指数级增长，但关于其潜在有害影响的数据有限。我们使用自旋捕获剂苯基 - N - 叔丁基硝酮（PBN），通过电子顺磁共振光谱（EPR）测试了电子烟烟雾中活性短寿命自由基的存在。在所有测试的电子烟、电子烟液（在3.3伏时每吸一口有2.5×10¹³至10.3×10¹³个自由基）、电子烟液溶剂丙二醇和甘油以及“干抽”产生的烟雾中均检测到自由基。这些结果首次证明了电子烟会产生具有高度氧化性的自由基，这可能对电子烟使用者构成潜在的毒理学风险。
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