Chander Russell Jude, Foo Heidi, Yong Tingting, Lim Levinia, Tan Jayne, Wen Ming-Ching, Ng Adeline, Hameed Shahul, Ting Simon, Zhou Juan, Kandiah Nagaendran
Department of Neurology, National Neuroscience Institute, Singapore 308433, Singapore.
Department of Neurology, Singapore General Hospital, Singapore 169856, Singapore.
Aging (Albany NY). 2018 Dec 12;10(12):3866-3880. doi: 10.18632/aging.101678.
Individuals with mild cognitive impairment (MCI) exhibit varying serial position effect (SPE) performances. The relationship between SPE performance in word list recall and clinical, genetic, and neuroimaging features of MCI requires elucidation. 119 MCI and 68 cognitively normal (CN) participants underwent cognitive assessment, apolipoprotein E (ApoE) genotyping, and volumetric MRI brain scans processed via voxel-based morphometry. A 10-word recall task was used to assess SPE performance in relation to recency and primacy recall. MCI participants were classified as having Good SPE performance (high primacy and recency, Good SPE) or Poor SPE performance (low primacy only, LP-SPE; low recency only, LR-SPE; or both low, Low SPE). Poor SPE participants had reduced grey matter (GM) volumes and increased white matter hyperintensities (WMH) volumes. Participants with LP-SPE demonstrated reduced hippocampal GM volumes and were more likely to be ApoE ε4 carriers. LR-SPE was associated with higher WMH volumes. Presence of both greater WMH volumes and ApoE ε4 resulted in Low SPE. LP-SPE MCI participants had features typical of Alzheimer's disease. LR-SPE MCI was associated with increased WMH volumes, likely representing vascular pathology. SPE profiles are associated with distinct clinical patterns of MCI pathophysiology and could have potential as a clinical marker.
轻度认知障碍（MCI）患者表现出不同的系列位置效应（SPE）表现。在单词列表回忆中，SPE表现与MCI的临床、遗传和神经影像学特征之间的关系需要阐明。119名MCI患者和68名认知正常（CN）参与者接受了认知评估、载脂蛋白E（ApoE）基因分型以及通过基于体素的形态学处理的脑容积磁共振成像扫描。一项10个单词的回忆任务用于评估与近因和首因回忆相关的SPE表现。MCI参与者被分类为具有良好的SPE表现（高首因和近因，良好的SPE）或较差的SPE表现（仅低首因，LP-SPE；仅低近因，LR-SPE；或两者均低，低SPE）。SPE表现较差的参与者灰质（GM）体积减少，白质高信号（WMH）体积增加。LP-SPE参与者海马GM体积减少，更有可能是ApoE ε4携带者。LR-SPE与较高的WMH体积相关。WMH体积较大和ApoE ε4同时存在导致低SPE。LP-SPE MCI参与者具有阿尔茨海默病的典型特征。LR-SPE MCI与WMH体积增加相关，可能代表血管病变。SPE特征与MCI病理生理学的不同临床模式相关，可能具有作为临床标志物的潜力。
