Chumak Vadim, Drozdovitch Vladimir, Kryuchkov Victor, Bakhanova Elena, Babkina Natalya, Bazyka Dimitry, Gudzenko Natalya, Hatch Maureen, Trotsuk Natalya, Zablotska Lydia, Golovanov Ivan, Luckyanov Nickolas, Voillequé Paul, Bouville André
*National Research Centre for Radiation Medicine, Kyiv, Ukraine; †Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD; ‡Burnasyan Federal Medical Biophysical Centre, Moscow, Russia; §Department of Epidemiology and Biostatistics, University of California, San Francisco, CA; **Retired; ††MJP Risk Assessment, Inc., Denver, CO.
Health Phys. 2015 Oct;109(4):296-301. doi: 10.1097/HP.0000000000000341.
This paper describes dose reconstruction for a joint Ukrainian-American case-control study of leukemia that was conducted in a cohort of 110,645 male Ukrainian cleanup workers of the Chornobyl (Chernobyl) accident who were exposed to various radiation doses over the 1986-1990 time period. Individual bone-marrow doses due to external irradiation along with respective uncertainty distributions were calculated for 1,000 study subjects using the RADRUE method, which employed personal cleanup history data collected in the course of an interview with the subject himself if he was alive or with two proxies if he was deceased. The central estimates of the bone-marrow dose distributions range from 3.7 × 10(-5) to 3,260 mGy, with an arithmetic mean of 92 mGy. The uncertainties in the individual stochastic dose estimates can be approximated by lognormal distributions; the average geometric standard deviation is 2.0.
本文描述了乌克兰-美国关于白血病的一项病例对照联合研究中的剂量重建情况。该研究针对110,645名参与清理工作的乌克兰男性进行，他们在1986 - 1990年期间受到切尔诺贝利（Chornobyl）事故不同辐射剂量的照射。使用RADRUE方法为1000名研究对象计算了因外部照射导致的个体骨髓剂量以及相应的不确定性分布，该方法采用了个人清理历史数据，若研究对象在世则通过对其本人访谈收集，若已去世则通过两位代理人收集。骨髓剂量分布的中心估计值范围为3.7×10⁻⁵至3260 mGy，算术平均值为92 mGy。个体随机剂量估计中的不确定性可用对数正态分布近似；平均几何标准差为2.0。
