Zor Erhan, Morales-Narváez Eden, Zamora-Gálvez Alejandro, Bingol Haluk, Ersoz Mustafa, Merkoçi Arben
ICN2-Catalan Institute of Nanoscience and Nanotechnology, Campus de la UAB , 08193 (Bellaterra) Barcelona, Spain.
Science and Technology Department, A.K. Faculty of Education, Necmettin Erbakan University , Konya, 42090, Turkey.
ACS Appl Mater Interfaces. 2015 Sep 16;7(36):20272-9. doi: 10.1021/acsami.5b05838. Epub 2015 Sep 2.
Due to their size and difficulty to obtain, cost/effective biological or synthetic receptors (e.g., antibodies or aptamers, respectively), organic toxic compounds (e.g., less than 1 kDa) are generally challenging to detect using simple platforms such as biosensors. This study reports on the synthesis and characterization of a novel multifunctional composite material, magnetic silica beads/graphene quantum dots/molecularly imprinted polypyrrole (mSGP). mSGP is engineered to specifically and effectively capture and signal small molecules due to the synergy among chemical, magnetic, and optical properties combined with molecular imprinting of tributyltin (291 Da), a hazardous compound, selected as a model analyte. Magnetic and selective properties of the mSGP composite can be exploited to capture and preconcentrate the analyte onto its surface, and its photoluminescent graphene quantum dots, which are quenched upon analyte recognition, are used to interrogate the presence of the contaminant. This multifunctional material enables a rapid, simple and sensitive platform for small molecule detection, even in complex mediums such as seawater, without any sample treatment.
由于其尺寸以及获取难度，具有成本效益的生物或合成受体（例如分别为抗体或适体）、有机有毒化合物（例如分子量小于1 kDa），通常很难使用诸如生物传感器这样的简单平台进行检测。本研究报道了一种新型多功能复合材料——磁性二氧化硅珠/石墨烯量子点/分子印迹聚吡咯（mSGP）的合成与表征。由于化学、磁性和光学性质之间的协同作用以及分子印迹技术，mSGP被设计用于特异性且有效地捕获小分子并发出信号，其中分子印迹技术针对的是一种被选作模型分析物的有害化合物——三丁基锡（291 Da）。mSGP复合材料的磁性和选择性特性可用于将分析物捕获并预浓缩到其表面，并且其光致发光的石墨烯量子点在识别分析物时会发生猝灭，用于检测污染物的存在。这种多功能材料为小分子检测提供了一个快速、简单且灵敏的平台，即使在诸如海水等复杂介质中，也无需任何样品处理。
