Li Yueli, Xiang Ying, Wu Na, Wu Long, Yu Zubin, Zhang Mengxuan, Wang Minghao, Jiang Jun, Li Yafei
Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, People's Republic of China.
Center for Clinical Epidemiology and Evidence-Based Medicine, Third Military Medical University, Chongqing, People's Republic of China.
World J Surg. 2015 Dec;39(12):2862-71. doi: 10.1007/s00268-015-3212-4.
This study aimed to systematically review and compare the perioperative outcomes of laparoscopy with laparotomy for abdominal trauma patients.
We conducted a systematic review and meta-analysis comparing the perioperative outcomes of laparoscopy with laparotomy for abdominal trauma patients. Clinical endpoints included length of hospital stay, operation time, amount of intraoperative blood loss, time to postoperative exhaust, time to regular diet, time to out of bed, duration of postoperative pain, postoperative complications, perioperative mortality rate, length of intensive care unit (ICU) stay, missed injuries, conversions to laparotomy, and cure rate.
Sixty-four studies including 9058 patients with abdominal trauma were included. In these studies, laparoscopy was used as a screening, diagnostic, or therapeutic tool. Meta-analysis showed significant reductions in the incidence of postoperative complications (relative risk [RR] [95 % confidence interval (CI)] 0.37 [0.29-0.46]), perioperative mortality rate (RR 0.64; 95 % CI 0.52-0.80), operation time (mean difference [MD] [95 % CI] -19.93 min [-34.43 to 5.43]), length of hospital stay (MD -5.15 days; 95 % CI -6.80 to 3.50), amount of intraoperative blood loss (MD -141.33 ml; 95 % CI -260.99 to 21.67), time to postoperative exhaust (MD -5.32 h; 95 % CI -8.60 to 2.05), time to regular diet (MD -3.46 h; 95 % CI -6.31 to 0.61), time to out of bed (MD -23.51 h; 95 % CI -24.85 to 22.16), duration of postoperative pain (MD -21.34 h; 95 % CI -22.65 to 20.03), length of ICU stay (MD -1.89 days; 95 % CI -4.05 to 0.27) in patients with abdominal trauma treated with laparoscopy compared with laparotomy. The pooled incidence of postoperative complications, missed injuries, conversions, and perioperative mortality rate of laparoscopy among the case reports were 0.04 (95 % CI 0.03-0.06), 0.01 (95 % CI 0.01-0.02), 0.24 (95 % CI 0.20-0.28), 0.01(95 % CI 0.01-0.02), respectively. Cure rate of laparoscopy ranged from 46 to 95 % and the pooled rate was 0.76 (95 % CI 0.71-0.81).
Laparoscopy is an effective way to improve perioperative outcomes and reduce the complications of hemodynamically stable patients with abdominal trauma. It is worth further popularization in clinical practice.
本研究旨在系统评价和比较腹腔镜手术与开腹手术治疗腹部创伤患者的围手术期结局。
我们进行了一项系统评价和荟萃分析,比较腹腔镜手术与开腹手术治疗腹部创伤患者的围手术期结局。临床终点包括住院时间、手术时间、术中失血量、术后排气时间、恢复正常饮食时间、下床活动时间、术后疼痛持续时间、术后并发症、围手术期死亡率、重症监护病房(ICU)住院时间、漏诊损伤、中转开腹手术以及治愈率。
纳入64项研究,共9058例腹部创伤患者。在这些研究中,腹腔镜手术被用作筛查、诊断或治疗工具。荟萃分析显示,与开腹手术相比,腹腔镜手术治疗腹部创伤患者的术后并发症发生率(相对危险度[RR][95%置信区间(CI)]0.37[0.29 - 0.46])、围手术期死亡率(RR 0.64;95% CI 0.52 - 0.80)、手术时间(平均差[MD][95% CI] - 19.93分钟[- 34.43至5.43])、住院时间(MD - 5.15天;95% CI - 6.80至3.50)、术中失血量(MD - 141.33毫升;95% CI - 260.99至21.67)、术后排气时间(MD - 5.32小时;95% CI - 8.60至2.05)、恢复正常饮食时间(MD - 3.46小时;95% CI - 6.31至0.61)、下床活动时间(MD - 23.51小时;95% CI - 24.85至22.16)、术后疼痛持续时间(MD - 21.34小时;95% CI - 22.65至20.03)、ICU住院时间(MD - 1.89天;95% CI - 4.05至0.27)均显著降低。病例报告中腹腔镜手术的术后并发症、漏诊损伤、中转手术及围手术期死亡率的合并发生率分别为0.04(95% CI为0.03 - 0.06)、0.01(95% CI为0.01 - 0.02)、0.24(95% CI为0.20 - 0.28)、0.01(95% CI为0.01 - 0.02)。腹腔镜手术的治愈率在46%至95%之间,合并率为0.76(95% CI为0.71 - 0.81)。
腹腔镜手术是改善血流动力学稳定的腹部创伤患者围手术期结局、减少并发症的有效方法。值得在临床实践中进一步推广。