Zhu Xiao-Cui, Zhang Jia-Li, Ge Chen-Tao, Yu Yuan-Yang, Wang Pan, Yuan Ti-Fei, Fu Cai-Yun
College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, People's Republic of China.
School of Psychology, Nanjing Normal University, Nanjing, People's Republic of China.
Drug Des Devel Ther. 2015 Aug 18;9:4239-45. doi: 10.2147/DDDT.S87568. eCollection 2015.
With the technological advances in cancer diagnosis and treatment, the survival rates for patients with cancer are prolonged. The issue of figuring out how to improve the life quality of patients with cancer has become increasingly prominent. Pain, especially bone pain, is the most common symptom in malignancy patients, which seriously affects the life quality of patients with cancer. The research of cancer pain has a breakthrough due to the development of the animal models of cancer pain in recent years, such as the animal models of mouse femur, humerus, calcaneus, and rat tibia. The establishment of several kinds of animal models related to cancer pain provides a new platform in vivo to investigate the molecular mechanisms of cancer pain. In this review, we focus on the advances of cancer pain from bone metastasis, the mechanisms involved in cancer pain, and the drug treatment of cancer pain in the animal models.
随着癌症诊断和治疗技术的进步，癌症患者的生存率得以延长。如何提高癌症患者生活质量的问题日益突出。疼痛，尤其是骨痛，是恶性肿瘤患者最常见的症状，严重影响癌症患者的生活质量。近年来，由于癌症疼痛动物模型的发展，如小鼠股骨、肱骨、跟骨以及大鼠胫骨的动物模型，癌症疼痛的研究取得了突破。几种与癌症疼痛相关的动物模型的建立为在体内研究癌症疼痛的分子机制提供了新的平台。在本综述中，我们重点关注骨转移导致的癌症疼痛的进展、癌症疼痛的相关机制以及动物模型中癌症疼痛的药物治疗。
