Di Bella Claudia, Fosang Amanda, Donati Davide M, Wallace Gordon G, Choong Peter F M
Department of Orthopaedic, St Vincent's Hospital , Melbourne, VIC , Australia ; Department of Surgery, University of Melbourne , Melbourne, VIC , Australia.
Murdoch Childrens Research Institute, University of Melbourne , Parkville, VIC , Australia.
Front Surg. 2015 Aug 13;2:39. doi: 10.3389/fsurg.2015.00039. eCollection 2015.
Chondral and osteochondral lesions represent one of the most challenging and frustrating scenarios for the orthopedic surgeon and for the patient. The lack of therapeutic strategies capable to reconstitute the function and structure of hyaline cartilage and to halt the progression toward osteoarthritis has brought clinicians and scientists together, to investigate the potential role of tissue engineering as a viable alternative to current treatment modalities. In particular, the role of bioprinting is emerging as an innovative technology that allows for the creation of organized 3D tissue constructs via a "layer-by-layer" deposition process. This process also has the capability to combine cells and biomaterials in an ordered and predetermined way. Here, we review the recent advances in cartilage bioprinting and we identify the current challenges and the directions for future developments in cartilage regeneration.
软骨和骨软骨损伤对于骨科医生和患者来说都是最具挑战性和令人沮丧的情况之一。缺乏能够重建透明软骨功能和结构并阻止骨关节炎进展的治疗策略，促使临床医生和科学家共同研究组织工程作为当前治疗方式可行替代方案的潜在作用。特别是，生物打印的作用正作为一种创新技术崭露头角，它允许通过“逐层”沉积过程创建有组织的三维组织构建体。这个过程还能够以有序且预先确定的方式将细胞和生物材料结合起来。在此，我们回顾软骨生物打印的最新进展，并确定软骨再生当前面临的挑战以及未来发展的方向。
