一种混合晶体镧系沸石类似的金属有机骨架作为荧光指示剂用于检测溶血磷脂酸，一种癌症生物标志物。
A mixed-crystal lanthanide zeolite-like metal-organic framework as a fluorescent indicator for lysophosphatidic acid, a cancer biomarker.
机构信息
Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE), Collaborative Innovation Center of Chemical Science and Engineering, Nankai University , Tianjin 300071, P. R. China.
Department of Chemical & Environmental Science and Materials and Surface Science Institute, University of Limerick , Limerick, Republic of Ireland.
出版信息
J Am Chem Soc. 2015 Sep 30;137(38):12203-6. doi: 10.1021/jacs.5b06929. Epub 2015 Sep 16.
Two lanthanide zeolite-like metal-organic frameworks (Ln-ZMOFs) with rho topology, Tb-ZMOF and Eu-ZMOF, were constructed by self-assembly of a 4-connected lanthanide molecular building block and a bipyridine-dicarboxylate ligand. Varying the Tb(3+) and Eu(3+) ratio during synthesis afforded three mixed-crystal isostructural MZMOFs with variable Eu:Tb stoichiometry. Fluorescence studies revealed that a methanol suspension of one of these mixed crystals, MZMOF-3, exhibits selective detection of lysophosphatidic acid (LPA), a biomarker for ovarian cancer and other gynecologic cancers. Linear correlation between the integrated fluorescence intensity and the concentration of LPA was observed, enabling quantitative analysis of LPA in physiologically relevant ranges (1.4-43.3 μM). MZMOF-3 therefore has the potential to act as a self-referencing and self-calibrating fluorescent indicator for LPA.
两种具有 rho 拓扑结构的镧系沸石型金属-有机骨架（Ln-ZMOFs），Tb-ZMOF 和 Eu-ZMOF，是通过 4 连接的镧系分子构建块和联吡啶-二羧酸配体的自组装构建而成。在合成过程中改变 Tb(3+)和 Eu(3+)的比例，可得到三种具有可变 Eu:Tb 化学计量比的同晶混合晶体 MZMOFs。荧光研究表明，这些混合晶体之一的甲醇悬浮液 MZMOF-3 对溶血磷脂酸（LPA）具有选择性检测能力，LPA 是卵巢癌和其他妇科癌症的生物标志物。观察到荧光强度积分与 LPA 浓度之间存在线性相关，从而能够在生理相关范围内（1.4-43.3 μM）对 LPA 进行定量分析。因此，MZMOF-3 有可能作为 LPA 的自参考和自校准荧光指示剂。
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