男性生殖细胞发育窗期中精子表观基因组的环境易感性
Environmental Susceptibility of the Sperm Epigenome During Windows of Male Germ Cell Development.
机构信息
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, 149 Goessmann, 686 North Pleasant Street, Amherst, MA, 01003, USA.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Building I 14th Floor, 665 Huntington Avenue, Boston, MA, 02115, USA.
出版信息
Curr Environ Health Rep. 2015 Dec;2(4):356-66. doi: 10.1007/s40572-015-0067-7.
Male germ cells require multiple epigenetic reprogramming events during their lifespan to achieve reproductive capacity. An emerging body of compelling data demonstrates that environmental exposures can be embodied within the developing male germ cell as epigenetic marks. In turn, these epigenetic marks can impart information at fertilization to affect the trajectory of offspring health and development. While it is recognized that in utero epigenetic reprogramming of male germ cells is a particularly susceptible window to environmental exposures, other such windows exist during germ cell development. The objective of this review is to discuss epigenetic reprogramming events during male germ cell development and to provide supporting evidence from animal and human studies that during specific periods of development, germ cells are susceptible to environmentally induced epigenetic errors. Moving forward, the nascent field of sperm epigenetics research is likely to advance our understanding of paternal environmental determinants of offspring health and development.
男性生殖细胞在其生命周期中需要多次表观遗传重编程事件才能实现生殖能力。越来越多的有力数据表明，环境暴露可以作为表观遗传标记体现在发育中的雄性生殖细胞中。反过来，这些表观遗传标记可以在受精时传递信息，影响后代健康和发育的轨迹。虽然人们认识到雄性生殖细胞的宫内表观遗传重编程是对环境暴露特别敏感的窗口，但在生殖细胞发育过程中还存在其他类似的窗口。本综述的目的是讨论雄性生殖细胞发育过程中的表观遗传重编程事件，并提供来自动物和人类研究的证据支持，即在特定的发育时期，生殖细胞易受到环境诱导的表观遗传错误的影响。展望未来，精子表观遗传学研究这一新兴领域可能会增进我们对父系环境决定后代健康和发育的理解。
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