Shalaby Mostafa Abbas, Hammouda Ashraf Abd-Elkhalik
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
J Intercult Ethnopharmacol. 2014 Apr-Jun;3(2):56-62. doi: 10.5455/jice.20140130015014. Epub 2014 May 28.
The aim was to evaluate the analgesic, anti-inflammatory, and anti-hyperlipidemic activities of Commiphora molmol extract (CME) and its effects on body weight and blood lipids.
The analgesic effect was assessed using thermal (hot plate test) and chemical (writhing test) stimuli to induce central and peripheral pain in mice. The anti-inflammatory activity was determined using formalin-induced paw edema in rats. For anti-hyperlipidemic effect, 25 rats were randomly divided into five groups (n = 5). Group 1 was fed on basal diet (normal control), while the other four groups were fed on high-fat diet for 6 weeks to induce obesity and hyperlipidemia. Thereafter, Group 2 was kept obese hyperlipidemic, and Groups 3, 4 and 5 were orally given CME in doses of 125, 250, and 500 mg/kg for 6 weeks, respectively. Body weight gains of rats were calculated, and blood samples were collected for analysis of blood lipids.
CME produced a dose-dependent analgesic effect using both hot plate and writhing tests in mice. The hot plate method appeared to be more sensitive than writhing test. CME exhibited an anti-inflammatory activity as it decreased volume of paw edema induced by formalin in rats. The extract decreased body weight gain; normalized the high levels of blood lipids and decreased atherogenic index low-density lipoprotein/ high-density lipoprotein in obese hyperlipidemic rats.
The results denote that C. molmol extract (myrrh) has significant analgesic, anti-inflammatory and anti-hyperlipidemic effects and reduces body weight gain and improves blood lipids profile. These results affirm the traditional use of C. molmol for the treatment of pain, inflammations, and hyperlipidemia.
本研究旨在评估没药提取物（CME）的镇痛、抗炎和抗高血脂活性，以及其对体重和血脂的影响。
采用热刺激（热板试验）和化学刺激（扭体试验）评估小鼠中枢和外周疼痛的镇痛效果。通过福尔马林诱导大鼠足爪肿胀来测定抗炎活性。对于抗高血脂作用，将25只大鼠随机分为五组（n = 5）。第1组喂食基础饲料（正常对照组），而其他四组喂食高脂饲料6周以诱导肥胖和高血脂。此后，第2组保持肥胖高血脂状态，第3、4和5组分别口服给予125、250和500 mg/kg的CME，持续6周。计算大鼠体重增加量，并采集血样分析血脂。
在热板试验和扭体试验中，CME对小鼠均产生剂量依赖性镇痛作用。热板法似乎比扭体试验更敏感。CME具有抗炎活性，因为它可减少福尔马林诱导的大鼠足爪肿胀体积。该提取物可降低体重增加量；使肥胖高血脂大鼠的高血脂水平恢复正常，并降低动脉粥样硬化指数低密度脂蛋白/高密度脂蛋白。
结果表明没药提取物具有显著的镇痛、抗炎和抗高血脂作用，可减轻体重增加并改善血脂谱。这些结果证实了没药在传统医学中用于治疗疼痛、炎症和高血脂的用途。
