Tsala David Emery, Habtemariam Solomon, Simplice Foyet Harquin, Martin Thierry Bella Ndzana, Abraham Jital Abraham, Theophile Dimo
'Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua, Cameroon.
Department of Pharmacology, Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Central Avenue, Chatham, Maritime, Kent ME4 4TB, UK.
J Intercult Ethnopharmacol. 2014 Apr-Jun;3(2):63-7. doi: 10.5455/jice.20140129034637. Epub 2014 May 30.
The objective of the present study was to evaluate the in vivo wound healing effect of water extract of Tetrapleura tetraptera in stem-bark.
The healing activity was studied in 40 male rats using excision and incision wounds on normal and dexamethasone-suppressed wound healing. For each model, rats were divided in four groups as follows: control, dexamethasone, T. tetraptera and dexamethasone combined with T. tetraptera.
Data recorded exhibited a significant effect by the extract in the epithelialization time within 14 and 18 days of the normal and dexamethasone-induced healing delay rats, respectively (P < 0.05). The extract also significantly increased the wound tensile strength in dexamethasone treated rats. Histological examination of incision wounds of the extract-treated group showed many fibroblasts and the same rats presented significant cutaneous tensile strength, suggesting important collagen crosslinkage.
This study illustrated an excellent potential of the bark of T. tetraptera therapy on dermal wound healing with a possible mechanism of action related to epithelialization, contraction, and tensile strength improvement.
本研究的目的是评估四翅四棱豆茎皮水提取物在体内的伤口愈合效果。
在40只雄性大鼠身上研究了其对正常伤口和地塞米松抑制的伤口愈合的切除和切开伤口的愈合活性。对于每个模型，将大鼠分为以下四组：对照组、地塞米松组、四翅四棱豆组和地塞米松联合四翅四棱豆组。
记录的数据显示，该提取物分别对正常愈合和地塞米松诱导愈合延迟的大鼠在14天和18天内的上皮化时间有显著影响（P<0.05）。该提取物还显著提高了地塞米松处理大鼠的伤口抗张强度。提取物处理组切开伤口的组织学检查显示有许多成纤维细胞，且相同大鼠表现出显著的皮肤抗张强度，提示有重要的胶原交联。
本研究表明四翅四棱豆树皮在皮肤伤口愈合方面具有良好的治疗潜力，其可能的作用机制与上皮化、收缩和抗张强度改善有关。
