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咖啡酸苯乙酯作为一种治疗生殖功能及基于氧化应激的性腺疾病的药物。

Caffeic acid phenethyl ester as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads.

作者信息

Akyol Sumeyya, Akbas Ali, Butun Ilknur, Toktas Muhsin, Ozyurt Huseyin, Sahin Semsettin, Akyol Omer

机构信息

Departments of Medical Biology, Faculty of Turgut Ozal University Medical, Ankara, Turkey ; Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.

Department of Biochemistry, Faculty of Gaziosmanpasa University Medical, Tokat, Turkey.

出版信息

J Intercult Ethnopharmacol. 2015 Apr-Jun;4(2):187-91. doi: 10.5455/jice.20150402062823. Epub 2015 Apr 3.

DOI:10.5455/jice.20150402062823
PMID:26401405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4566781/
Abstract

In recent years, the studies on the roles of caffeic acid phenethyl ester (CAPE) in several disease models and cell cultures are tremendously growing. It is such a great molecule that was used by ancient times to ameliorate some diseases and nowadays, it is used by modern medicine to test the effectiveness. In this mini-review article, the protection capability of CAPE, as a liposoluble antioxidant and a potent nuclear factor kappa B inhibitor, on oxidative and non-oxidative ovary, and testis damages has been summarized. In view of our laboratory findings/experience and those reported in the hitherto literature, we suggest that CAPE possesses protective effects for pathologies of the reproductive organs induced by untoward effects of harmful molecules such as free oxygen radicals, pesticides, methotrexate, and MK-801 (dizocilpine).

摘要

近年来，关于咖啡酸苯乙酯（CAPE）在多种疾病模型和细胞培养中的作用的研究正在迅猛发展。它是一种非常了不起的分子，古代就被用于改善某些疾病，如今现代医学也用它来测试疗效。在这篇小型综述文章中，总结了CAPE作为一种脂溶性抗氧化剂和一种有效的核因子κB抑制剂，对氧化和非氧化状态下卵巢及睾丸损伤的保护能力。鉴于我们实验室的研究结果/经验以及迄今文献中所报道的内容，我们认为CAPE对由诸如游离氧自由基、农药、甲氨蝶呤和MK - 801（地佐环平）等有害分子的不良影响所导致的生殖器官病变具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d7/4566781/f87988a4db86/JIE-4-187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d7/4566781/08c16221ed8c/JIE-4-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d7/4566781/f87988a4db86/JIE-4-187-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d7/4566781/08c16221ed8c/JIE-4-187-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1d7/4566781/f87988a4db86/JIE-4-187-g002.jpg

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Invest New Drugs. 2012 Feb;30(1):186-90. doi: 10.1007/s10637-010-9550-z. Epub 2010 Oct 6.
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Antiangogenic effect of selected phytochemicals.
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Heliyon. 2021 May 5;7(5):e06965. doi: 10.1016/j.heliyon.2021.e06965. eCollection 2021 May.
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