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甲氨蝶呤治疗儿童发热性溃疡性坏死性穆查-哈伯曼病:病例报告及文献综述

Methotrexate Treatment in Children with Febrile Ulceronecrotic Mucha-Habermann Disease: Case Report and Literature Review.

作者信息

Bulur Isil, Kaya Erdoğan Hilal, Nurhan Saracoglu Zeynep, Arık Deniz

机构信息

Department of Dermatology and Venereology, Faculty of Medicine, Osmangazi University, Eskişehir, Turkey.

Department of Pathology, Faculty of Medicine, Osmangazi University, Eskişehir, Turkey.

出版信息

Case Rep Dermatol Med. 2015;2015:357973. doi: 10.1155/2015/357973. Epub 2015 Aug 27.

DOI:10.1155/2015/357973
PMID:26413356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4564610/
Abstract

Febrile Ulceronecrotic Mucha-Habermann disease is a rare and potentially fatal variant of pityriasis lichenoides et varioliformis acuta and is characterized by high fever, constitutional symptoms, and acute oncet of ulceronecrotic lesions. We present an 11-year-old male with Febrile Ulceronecrotic Mucha-Habermann disease who was cured with methotrexate and review the use of methotrexate for this disorder in the pediatric age group with the relevant literature.

摘要

发热性溃疡坏死性穆恰-哈伯曼病是急性痘疮样苔藓样糠疹的一种罕见且可能致命的变异型,其特征为高热、全身症状以及溃疡坏死性皮损的急性发作。我们报告一名患发热性溃疡坏死性穆恰-哈伯曼病的11岁男性,其经甲氨蝶呤治愈,并结合相关文献综述甲氨蝶呤在儿童年龄组中对该疾病的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a50/4564610/16259ae747d6/CRIDM2015-357973.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a50/4564610/16259ae747d6/CRIDM2015-357973.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a50/4564610/16259ae747d6/CRIDM2015-357973.001.jpg

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本文引用的文献

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Febrile ulceronecrotic Mucha-Habermann disease: treatment with infliximab and intravenous immunoglobulins and review of the literature.发热性坏死性蕈样肉芽肿病:英夫利昔单抗和静脉注射免疫球蛋白治疗,并文献复习。
Dermatology. 2012;225(4):344-8. doi: 10.1159/000346245. Epub 2013 Jan 31.
2
Febrile ulceronecrotic Mucha-Habermann disease: a case with systemic symptoms managed with subcutaneous methotrexate.发热性溃疡性坏死性蕈样肉芽肿病:一例伴全身症状的病例,采用皮下注射甲氨蝶呤治疗。
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3
Febrile ulceronecrotic Mucha-Habermann disease with central nervous system vasculitis.
一名成年女性发热性溃疡性坏死性穆查-哈伯曼病的诊断难题病例,经甲氨蝶呤和环孢素成功治疗
Case Rep Dermatol. 2021 Jan 21;13(1):12-17. doi: 10.1159/000511537. eCollection 2021 Jan-Apr.
伴有中枢神经系统血管炎的发热性溃疡性坏死性穆查-哈伯曼病
Pediatr Dermatol. 2013 Jan-Feb;30(1):90-3. doi: 10.1111/j.1525-1470.2011.01669.x. Epub 2012 Jan 26.
4
Febrile ulceronecrotic Mucha-Habermann disease (pityriasis lichenoides et varioliformis acuta fulminans) presenting as Stevens-Johnson syndrome.表现为史蒂文斯-约翰逊综合征的发热性溃疡性坏死性穆查-哈贝曼病(急性痘疮样苔藓样糠疹暴发型)
Pediatr Dermatol. 2012 Mar-Apr;29(2):135-40. doi: 10.1111/j.1525-1470.2011.01608.x. Epub 2011 Nov 16.
5
Febrile ulceronecrotic Mucha-Habermann disease in a 34-month-old boy: a case report and review of the literature.一名34个月大男孩的发热性溃疡性坏死性穆夏-哈贝曼病:病例报告及文献复习
Pediatr Dermatol. 2012 Jan-Feb;29(1):53-8. doi: 10.1111/j.1525-1470.2011.01531.x. Epub 2011 Sep 9.
6
Febrile ulceronecrotic Mucha-Habermann's disease with pulmonary involvement.
Pediatr Dermatol. 2010 May-Jun;27(3):290-3. doi: 10.1111/j.1525-1470.2010.01141.x.
7
Pityriasis lichenoides et varioliformis acuta: a disease spectrum.急性苔藓样糠疹和痘疮样糠疹:一种疾病谱。
Int J Dermatol. 2010 Mar;49(3):257-61. doi: 10.1111/j.1365-4632.2008.03915.x.
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Febrile ulceronecrotic Mucha-Habermann disease: a rare dermatological emergency.
Clin Exp Dermatol. 2009 Dec;34(8):e1006-7. doi: 10.1111/j.1365-2230.2009.03666.x.
9
Intravenous immunoglobulins: a valuable asset in the treatment of a case of septic febrile ulceronecrotic Mucha-Habermann disease.静脉注射免疫球蛋白:治疗一例脓毒性发热性溃疡性坏死性穆恰-哈伯曼病的宝贵药物。
Dermatology. 2007;215(2):164-5. doi: 10.1159/000104271.
10
Septic, CD-30 positive febrile ulceronecrotic pityriasis lichenoides et varioliformis acuta.脓毒性、CD-30阳性的发热性溃疡性坏死性苔藓样糠疹及急性痘疮样苔藓样糠疹。
Pediatr Dermatol. 2005 Jul-Aug;22(4):360-5. doi: 10.1111/j.1525-1470.2005.22418.x.