Houda Mejri, Derbré Séverine, Jedy Ahmed, Tlili Nizar, Legault Jean, Richomme Pascal, Limam Ferid, Saidani-Tounsi Moufida
Laboratory of Bioactive Substances, Biotechnology Center, Technopark of Borj-Cedria, BP 901, 2050 Hammam-Lif, Tunisia ; University of Angers, Laboratoire des Substances d'Origine Naturelle et Analogues Structuraux, SONAS-EA 921, IFR 149 QUASAV, 16 Bd Daviers, 49045 Angers, France.
University of Angers, Laboratoire des Substances d'Origine Naturelle et Analogues Structuraux, SONAS-EA 921, IFR 149 QUASAV, 16 Bd Daviers, 49045 Angers, France.
EXCLI J. 2014 Sep 5;13:1029-42. eCollection 2014.
Oxidative stress and advanced glycation end products (AGEs) are known as key factors for the development of diabetic complications such as retinopathy, cataract as well as atherosclerosis and neurodegenerative diseases, including Alzheimer's diseases. In this context, natural products have been previously identified as promising sources for antioxidant and anti-glycation compounds. The current study focuses on the evaluation of antioxidant and glycation inhibitory activities of different solvent extracts of Solanum elaeagnifolium Cav (Solanaceae) fruits at different ripening stages. The results showed that antioxidant and anti-AGEs activities were significantly influenced by solvents polarities and ripening stages of S. elaeagnifolium Cav. With one exception, methanolic extract of overripe S. elaeagnifolium Cav fruit showed important protective effects against cellular oxidative stress. The aqueous extract showed the highest ABTS(+) scavenging ability. Principal component analysis showed that total phenolic and flavonoid contents correlated well with observed antioxidants and anti-glycation activities. These results bring attention to the possible use of S. elaeagnifolium Cav as a valuable source of bioactive compounds exhibiting antioxidant effects and potentially alleviating diabetic complications.
氧化应激和晚期糖基化终产物（AGEs）被认为是糖尿病并发症（如视网膜病变、白内障以及动脉粥样硬化和神经退行性疾病，包括阿尔茨海默病）发展的关键因素。在此背景下，天然产物此前已被确定为抗氧化和抗糖化化合物的有前景来源。当前研究聚焦于评估茄科植物银叶茄（Solanum elaeagnifolium Cav）果实不同成熟阶段的不同溶剂提取物的抗氧化和糖基化抑制活性。结果表明，抗氧化和抗AGEs活性受到银叶茄溶剂极性和成熟阶段的显著影响。除了一个例外，过熟银叶茄果实的甲醇提取物对细胞氧化应激显示出重要的保护作用。水提取物表现出最高的ABTS(+)清除能力。主成分分析表明，总酚和黄酮含量与观察到的抗氧化和抗糖化活性密切相关。这些结果引起了人们对银叶茄作为具有抗氧化作用并可能缓解糖尿病并发症的生物活性化合物宝贵来源的潜在用途的关注。
