Cohen Jean Marie, Silva Maria Laura, Caini Saverio, Ciblak Meral, Mosnier Anne, Daviaud Isabelle, Matias Gonçalo, Badur Selim, Valette Martine, Enouf Vincent, Paget John, Fleming Douglas M
Open Rome (Organize and Promote Epidemiological Network), Paris, France; Réseau des GROG, Paris, France.
Open Rome (Organize and Promote Epidemiological Network), Paris, France.
PLoS One. 2015 Oct 1;10(10):e0139431. doi: 10.1371/journal.pone.0139431. eCollection 2015.
Influenza B represents a high proportion of influenza cases in some seasons (even over 50%). The Influenza B study in General Practice (IBGP) is a multicenter study providing information about the clinical, demographic and socio-economic characteristics of patients affected by lab-confirmed influenza A or B. Influenza B patients and age-matched influenza A patients were recruited within the sentinel surveillance networks of France and Turkey in 2010-11 and 2011-12 seasons. Data were collected for each patient at the swab test day, after 9±2 days and, if not recovered, after 28±5 days. It was related to patient's characteristics, symptoms at presentation, vaccination status, prescriptions of antibiotics and antivirals, duration of illness, follow-up consultations in general practice or emergency room. We performed descriptive analyses and developed a multiple regression model to investigate the effect of patients and disease characteristics on the duration of illness. Overall, 774 influenza cases were included in the study: 419 influenza B cases (209 in France and 210 in Turkey) and 355 influenza A cases (205 in France and 150 in Turkey). There were no differences between influenza A and B patients in terms of clinical presentation and number of consultations with a practitioner; however, the use of antivirals was higher among influenza B patients in both countries. The average (median) reported duration of illness in the age groups 0-14 years, 15-64 years and 65+ years was 7.4 (6), 8.7 (8) and 10.5 (9) days in France, and 6.3 (6), 8.2 (7) and 9.2 (6) days in Turkey; it increased with age but did not differ by virus type; increased duration of illness was associated with antibiotics prescription. In conclusion, our findings show that influenza B infection appears not to be milder disease than influenza A infection.
在某些季节，乙型流感在流感病例中占比很高（甚至超过50%）。基层医疗中的乙型流感研究（IBGP）是一项多中心研究，提供有关实验室确诊的甲型或乙型流感患者的临床、人口统计学和社会经济特征的信息。2010 - 11年和2011 - 12年季节期间，在法国和土耳其的哨点监测网络中招募了乙型流感患者和年龄匹配的甲型流感患者。在拭子检测当天、9±2天后（如未康复，则在28±5天后）为每位患者收集数据。这些数据涉及患者特征、就诊时的症状、疫苗接种状况、抗生素和抗病毒药物的处方、病程、基层医疗或急诊室的随访咨询情况。我们进行了描述性分析，并建立了多元回归模型来研究患者和疾病特征对病程的影响。总体而言，该研究纳入了774例流感病例：419例乙型流感病例（法国209例，土耳其210例）和355例甲型流感病例（法国205例，土耳其150例）。甲型和乙型流感患者在临床表现和与医生的会诊次数方面没有差异；然而，在这两个国家，乙型流感患者使用抗病毒药物的比例更高。在法国，0 - 14岁、15 - 64岁和65岁以上年龄组报告的平均（中位数）病程分别为7.4（天）[中位数6天]、8.7（天）[中位数8天]和10.5（天）[中位数9天]；在土耳其，相应年龄组分别为6.3（天）[中位数6天]、8.2（天）[中位数7天]和9.2（天）[中位数6天]；病程随年龄增长而增加，但在病毒类型之间没有差异；病程延长与抗生素处方有关。总之，我们的研究结果表明，乙型流感感染似乎并不比甲型流感感染病情更轻。
