Characterization of HTLV-I in a T-cell line established from a patient with myelopathy. - Suppr | 超能文献

Characterization of HTLV-I in a T-cell line established from a patient with myelopathy.

作者信息

Nakamura T, Tsujihata M, Shirabe S, Matsuo H, Ueki Y, Nagataki S

机构信息

First Department of Internal Medicine, Nagasaki, University School of Medicine, Japan.

出版信息

Arch Neurol. 1989 Jan;46(1):35-7. doi: 10.1001/archneur.1989.00520370037015.

DOI:10.1001/archneur.1989.00520370037015

Abstract

We have established an interleukin 2-dependent, OKT4-positive T-cell line, named HCT-1, from cells in the cerebrospinal fluid obtained from a patient with human T-cell lymphotropic virus type I (HTLV-1)-associated myelopathy. Antigens for HTLV-I were detected in HCT-1 cells by indirect immunofluorescence and Western blot testing, and type C virus particles were detected by electron microscopy. Southern blot analysis of HCT-1 cellular DNA, using an HTLV-I probe, revealed that the integrated provirus genome could not be distinguished from the HTLV-I genome in adult patients with T-cell leukemia.

摘要

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