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艰难梭菌反复感染中的粪便微生物群移植:法国粪便微生物群移植小组的建议

Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation.

作者信息

Sokol Harry, Galperine Tatiana, Kapel Nathalie, Bourlioux Pierre, Seksik Philippe, Barbut Frederic, Scanzi Julien, Chast François, Batista Rui, Joly Francisca, Joly Anne-Christine, Collignon Anne, Guery Benoit, Beaugerie Laurent

机构信息

Gastroenterology and Nutrition Department, AP-HP, Saint-Antoine Hospital and UPMC Paris 06 University, GRC n°03, SUVIMIC, Paris, France.

Infectious Diseases Department, Huriez Hospital, CHRU Lille, Lille 2 University, France.

出版信息

Dig Liver Dis. 2016 Mar;48(3):242-7. doi: 10.1016/j.dld.2015.08.017. Epub 2015 Sep 7.

Abstract

Faecal microbiota transplantation is effective for treating recurrent forms of Clostridium difficile infection and its use in this indication is recommended in the most recent European and North American guidelines. In this context, faecal microbiota transplantation is beginning to be performed in France in clinical practice, while the rules governing this procedure have been defined in France only for clinical trials. To unify, secure, and evaluate practice in this field in France, the French Group of Faecal microbiota Transplantation (FGFT) was created in October 2014 with the support of the French National Society of Gastroenterology, the French Infectious Disease Society, and the National Academy of Pharmacy. We present here the deliberations of this group regarding the use of faecal microbiota transplantation for recurrent Clostridium difficile infection. The issues addressed are the indications, therapeutic sequence, delivery procedures, donor selection, methods and conditions of specimen preparation, and traceability.

摘要

粪便微生物群移植对于治疗复发性艰难梭菌感染有效,且最新的欧洲和北美指南推荐将其用于这一适应症。在此背景下,法国临床实践中已开始开展粪便微生物群移植,而法国仅针对临床试验制定了该程序的相关规则。为统一、规范并评估法国该领域的实践,法国粪便微生物群移植小组(FGFT)于2014年10月在法国国家胃肠病学会、法国传染病学会和国家药学科学院的支持下成立。我们在此介绍该小组关于使用粪便微生物群移植治疗复发性艰难梭菌感染的讨论情况。涉及的问题包括适应症、治疗顺序、给药程序、供体选择、标本制备方法和条件以及可追溯性。

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