肯尼亚普通成年人群中口服液体HIV自我检测的准确性和可接受性
Accuracy and Acceptability of Oral Fluid HIV Self-Testing in a General Adult Population in Kenya.
作者信息
Kurth Ann E, Cleland Charles M, Chhun Nok, Sidle John E, Were Edwin, Naanyu Violet, Emonyi Wilfred, Macharia Stephen M, Sang Edwin, Siika Abraham M
机构信息
New York University College of Nursing, 433 First Avenue, 7th Floor, New York, NY, 10003, USA.
Department of General Internal Medicine, School of Medicine, Indiana University, Indianapolis, IN, USA.
出版信息
AIDS Behav. 2016 Apr;20(4):870-9. doi: 10.1007/s10461-015-1213-9.
We evaluated performance, accuracy, and acceptability parameters of unsupervised oral fluid (OF) HIV self-testing (HIVST) in a general population in western Kenya. In a prospective validation design, we enrolled 240 adults to perform rapid OF HIVST and compared results to staff administered OF and rapid fingerstick tests. All reactive, discrepant, and a proportion of negative results were confirmed with lab ELISA. Twenty participants were video-recorded conducting self-testing. All participants completed a staff administered survey before and after HIVST to assess attitudes towards OF HIVST acceptability. HIV prevalence was 14.6 %. Thirty-six of the 239 HIVSTs were invalid (15.1 %; 95 % CI 11.1-20.1 %), with males twice as likely to have invalid results as females. HIVST sensitivity was 89.7 % (95 % CI 73-98 %) and specificity was 98 % (95 % CI 89-99 %). Although sensitivity was somewhat lower than expected, there is clear interest in, and high acceptability (94 %) of OF HIV self-testing.
我们评估了肯尼亚西部普通人群中无监督口服液体（OF）HIV自我检测（HIVST）的性能、准确性和可接受性参数。在一项前瞻性验证设计中，我们招募了240名成年人进行快速OF HIVST，并将结果与工作人员进行的OF和快速指尖检测结果进行比较。所有反应性、不一致性和一部分阴性结果均通过实验室ELISA进行确认。对20名参与者进行了自我检测的视频记录。所有参与者在HIVST前后都完成了工作人员进行的调查，以评估对OF HIVST可接受性的态度。HIV流行率为14.6%。239次HIVST中有36次无效（15.1%；95%CI 11.1 - 20.1%），男性出现无效结果的可能性是女性的两倍。HIVST的敏感性为89.7%（95%CI 73 - 98%），特异性为98%（95%CI 89 - 99%）。尽管敏感性略低于预期，但人们对OF HIV自我检测有明显兴趣，且接受度较高（94%）。
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