翻译的扫描模型：最新进展。
The scanning model for translation: an update.
作者信息
Kozak M
机构信息
Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.
出版信息
J Cell Biol. 1989 Feb;108(2):229-41. doi: 10.1083/jcb.108.2.229.
Abstract
The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.
摘要
真核生物核糖体的小（40S）亚基据信最初结合在信使RNA的5'端帽状结构处，然后迁移，在一个有利于起始翻译的合适环境中遇到第一个AUG密码子便停止。首个AUG规则并非绝对，但存在打破该规则的规则。一些看似与扫描机制相矛盾的异常观察结果现在看来是人为现象。仍有一些真正的异常现象无法解释。
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本文引用的文献
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