Ng C S, Chick W, Tsao S Y, O S K, Sung J Y, Lee J C, Shiu W, Cheng P N, Martin W M
Oncology. 1987;44(1):38-41. doi: 10.1159/000226440.
Peripheral blood lymphocyte subsets were studied in 29 untreated Chinese nasopharyngeal carcinoma (NPC) patients and 20 normal controls of similar age range and sex ratio with indirect immunofluorescence using monoclonal antibodies. The percentage T lymphocyte (T11) count, percentage and absolute T helper (T4) lymphocyte counts and the T helper/T suppressor-cytotoxic cell ratio (T4/T8) were significantly lower, while the percentage and absolute T8 counts were significantly higher in NPC patients. Concerning B lymphocytes, B1 cell count was normal while B4 cell count (B lymphocytes including early B lymphocytes) was significantly lower in NPC patients. These various lymphocyte subset changes were not related to the clinical stage or to Epstein-Barr viral IgA viral capsid antibodies and IgA early antibodies. The pathogenetic and prognostic significance of peripheral blood lymphocyte changes in NPC requires further investigation.
采用单克隆抗体间接免疫荧光法，对29例未经治疗的中国鼻咽癌（NPC）患者及20例年龄范围和性别比例相近的正常对照者的外周血淋巴细胞亚群进行了研究。鼻咽癌患者的T淋巴细胞百分比（T11）计数、T辅助淋巴细胞百分比及绝对计数以及T辅助/抑制细胞毒性细胞比值（T4/T8）显著降低，而T8细胞百分比及绝对计数显著升高。关于B淋巴细胞，鼻咽癌患者的B1细胞计数正常，而B4细胞计数（包括早期B淋巴细胞的B淋巴细胞）显著降低。这些淋巴细胞亚群的各种变化与临床分期、EB病毒IgA病毒衣壳抗体及IgA早期抗体无关。鼻咽癌外周血淋巴细胞变化的发病机制及预后意义有待进一步研究。
