视紫红质-抑制蛋白复合物的结构快照。
A structural snapshot of the rhodopsin-arrestin complex.
作者信息
Kang Yanyong, Gao Xiang, Zhou X Edward, He Yuanzheng, Melcher Karsten, Xu H Eric
机构信息
Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, MI, USA.
VARI-SIMM Center, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
出版信息
FEBS J. 2016 Mar;283(5):816-21. doi: 10.1111/febs.13561. Epub 2015 Nov 7.
Abstract
The crystal structure of the rhodopsin-arrestin complex provides important insights into how G protein-coupled receptor signaling is terminated by arrestin and a structural basis for understanding the mechanism of arrestin-based signaling.
摘要
视紫红质-抑制蛋白复合物的晶体结构为理解抑制蛋白如何终止G蛋白偶联受体信号传导提供了重要见解，并为理解基于抑制蛋白的信号传导机制提供了结构基础。
相似文献
1
A structural snapshot of the rhodopsin-arrestin complex.视紫红质-抑制蛋白复合物的结构快照。
FEBS J. 2016 Mar;283(5):816-21. doi: 10.1111/febs.13561. Epub 2015 Nov 7.
2
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.通过飞秒X射线激光获得的视紫红质与抑制蛋白结合的晶体结构。
Nature. 2015 Jul 30;523(7562):561-7. doi: 10.1038/nature14656. Epub 2015 Jul 22.
3
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.鉴定G蛋白偶联受体招募抑制蛋白的磷酸化编码
Cell. 2017 Jul 27;170(3):457-469.e13. doi: 10.1016/j.cell.2017.07.002.
4
Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.抑制蛋白与G蛋白偶联受体的相互作用。野生型和突变型抑制蛋白与视紫红质、β2-肾上腺素能受体和M2毒蕈碱胆碱能受体的直接结合研究。
J Biol Chem. 1995 Jan 13;270(2):720-31. doi: 10.1074/jbc.270.2.720.
5
Visualization of arrestin recruitment by a G-protein-coupled receptor.G 蛋白偶联受体介导的 arrestin 募集的可视化
Nature. 2014 Aug 14;512(7513):218-222. doi: 10.1038/nature13430. Epub 2014 Jun 22.
6
G protein-coupled receptors--recent advances.G蛋白偶联受体——最新进展
Acta Biochim Pol. 2012;59(4):515-29. Epub 2012 Dec 18.
7
Conformational changes in the phosphorylated C-terminal domain of rhodopsin during rhodopsin arrestin interactions.视紫红质与抑制蛋白相互作用过程中视紫红质磷酸化C末端结构域的构象变化。
J Biol Chem. 2004 Dec 3;279(49):51203-7. doi: 10.1074/jbc.M407341200. Epub 2004 Sep 6.
8
Arrestin interactions with G protein-coupled receptors.抑制蛋白与G蛋白偶联受体的相互作用。
Handb Exp Pharmacol. 2014;219:15-56. doi: 10.1007/978-3-642-41199-1_2.
9
Binding of purified recombinant beta-arrestin to guanine-nucleotide-binding-protein-coupled receptors.纯化的重组β-抑制蛋白与鸟嘌呤核苷酸结合蛋白偶联受体的结合。
Eur J Biochem. 1995 Sep 1;232(2):464-72.
10
Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process.GPCR 视紫红质中螺旋 8 的构象动力学控制了脱敏过程中抑制蛋白的激活。
Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18690-5. doi: 10.1073/pnas.1015461108. Epub 2011 Oct 28.
引用本文的文献
1
Intersection of GPCR trafficking and cAMP signaling at endomembranes.G蛋白偶联受体（GPCR）在内膜上的运输与环磷酸腺苷（cAMP）信号传导的交汇
J Cell Biol. 2025 Apr 7;224(4). doi: 10.1083/jcb.202409027. Epub 2025 Mar 25.
2
Lipid-based liquid crystalline materials in electrochemical sensing and nanocarrier technology.基于脂质的液晶材料在电化学生物传感和纳米载体技术中的应用。
Mikrochim Acta. 2023 Apr 18;190(5):187. doi: 10.1007/s00604-023-05727-w.
3
β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells.β-arrestin1 和 2 在与活细胞中相同的 GPCR 偶联时表现出不同的依赖于磷酸化的构象。
Nat Commun. 2022 Sep 26;13(1):5638. doi: 10.1038/s41467-022-33307-8.
4
Rhodopsin as a Molecular Target to Mitigate Retinitis Pigmentosa.视紫红质作为减轻视网膜色素变性的分子靶标。
Adv Exp Med Biol. 2022;1371:61-77. doi: 10.1007/5584_2021_682.
5
An arrestin-1 surface opposite of its interface with photoactivated rhodopsin engages with enolase-1. Arrestin-1 的表面与光激活视紫红质的界面相对的部位与烯醇酶-1 结合。
J Biol Chem. 2020 May 8;295(19):6498-6508. doi: 10.1074/jbc.RA120.013043. Epub 2020 Apr 1.
6
Revealing the architecture of protein complexes by an orthogonal approach combining HDXMS, CXMS, and disulfide trapping.通过结合氢氘交换质谱（HDXMS）、交联质谱（CXMS）和二硫键捕捉的正交方法揭示蛋白质复合物的结构。
Nat Protoc. 2018 Jun;13(6):1403-1428. doi: 10.1038/nprot.2018.037. Epub 2018 May 24.
7
The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants.视紫红质的细胞质尾部在驱动蛋白-2突变体中引发快速的视杆细胞退化。
J Biol Chem. 2017 Oct 20;292(42):17375-17386. doi: 10.1074/jbc.M117.784017. Epub 2017 Aug 30.
8
Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation.β-抑制蛋白的核心结合对于激动剂诱导的血管加压素受体内吞作用和细胞外信号调节激酶激活并非必需。
Mol Biol Cell. 2017 Apr 15;28(8):1003-1010. doi: 10.1091/mbc.E16-12-0818. Epub 2017 Feb 22.
9
Cannabinoid Receptor Interacting Protein 1a Competition with β-Arrestin for CB1 Receptor Binding Sites.大麻素受体相互作用蛋白1a与β-抑制蛋白竞争CB1受体结合位点。
Mol Pharmacol. 2017 Feb;91(2):75-86. doi: 10.1124/mol.116.104638. Epub 2016 Nov 28.
10
Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae.差异磷酸化提供了一种开关，用于控制α-抑制蛋白Rod1如何下调酿酒酵母中的交配信息素反应。
Genetics. 2016 May;203(1):299-317. doi: 10.1534/genetics.115.186122. Epub 2016 Feb 26.
本文引用的文献
1
Visualization of arrestin recruitment by a G-protein-coupled receptor.G 蛋白偶联受体介导的 arrestin 募集的可视化
Nature. 2014 Aug 14;512(7513):218-222. doi: 10.1038/nature13430. Epub 2014 Jun 22.
2
Femtosecond crystallography of membrane proteins in the lipidic cubic phase.脂质立方相中膜蛋白的飞秒晶体学
Philos Trans R Soc Lond B Biol Sci. 2014 Jul 17;369(1647):20130314. doi: 10.1098/rstb.2013.0314.
3
Crystallographic data processing for free-electron laser sources.自由电子激光源的晶体学数据处理
Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1231-40. doi: 10.1107/S0907444913013620. Epub 2013 Jun 15.
4
Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.活性β-arrestin-1 与 G 蛋白偶联受体磷酸肽结合的结构。
Nature. 2013 May 2;497(7447):137-41. doi: 10.1038/nature12120. Epub 2013 Apr 21.
5
Crystal structure of pre-activated arrestin p44.预激活的 arrestin p44 的晶体结构。
Nature. 2013 May 2;497(7447):142-6. doi: 10.1038/nature12133. Epub 2013 Apr 21.
6
High-resolution protein structure determination by serial femtosecond crystallography.利用连续飞秒晶体学技术测定高分辨率蛋白质结构。
Science. 2012 Jul 20;337(6092):362-4. doi: 10.1126/science.1217737. Epub 2012 May 31.
7
Structure and activation of rhodopsin.视紫红质的结构与激活
Acta Pharmacol Sin. 2012 Mar;33(3):291-9. doi: 10.1038/aps.2011.171. Epub 2012 Jan 23.
8
Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.分子模拟通过 SnRK2 激酶和 PP2C 磷酸酶调节 ABA 信号转导。
Science. 2012 Jan 6;335(6064):85-8. doi: 10.1126/science.1215106. Epub 2011 Nov 24.
9
Crystal structure of the β2 adrenergic receptor-Gs protein complex.β2 肾上腺素能受体-Gs 蛋白复合物的晶体结构。
Nature. 2011 Jul 19;477(7366):549-55. doi: 10.1038/nature10361.
10
Crystal structure of metarhodopsin II.视紫红质 II 的晶体结构。
Nature. 2011 Mar 31;471(7340):651-5. doi: 10.1038/nature09789. Epub 2011 Mar 9.
Zotero 插件