Sedaghati Tina, Seifalian Alexander M
Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK.
Centre for Nanotechnology and Regenerative Medicine, Division of Surgery & Interventional Science, University College London, London, UK ; Royal Free NHS Trust Foundation Hospital, London, UK ; NanoRegMed Ltd, London, UK.
Neural Regen Res. 2015 Aug;10(8):1191-4. doi: 10.4103/1673-5374.162678.
There is a high clinical demand for new smart biomaterials, which stimulate neuronal cell proliferation, migration and increase cell-material interaction to facilitate nerve regeneration across these critical-sized defects. This article briefly reviews several up-to-date published studies using Arginine-Glycine-Aspartic acid peptide sequence, nanocomposite based on polyhedral oligomeric silsesquioxane nanoparticle and nanofibrous scaffolds as promising strategies to enhance peripheral nerve regeneration by influencing cellular behaviour such as attachment, spreading and proliferation. The aim is to establish the potent manipulations, which are simple and easy to employ in the clinical conditions for nerve regeneration and repair.
对新型智能生物材料有很高的临床需求，这些材料可刺激神经元细胞增殖、迁移并增强细胞与材料的相互作用，以促进在这些临界尺寸缺损处的神经再生。本文简要回顾了几项最新发表的研究，这些研究使用精氨酸 - 甘氨酸 - 天冬氨酸肽序列、基于多面体低聚倍半硅氧烷纳米颗粒的纳米复合材料和纳米纤维支架，作为通过影响细胞行为（如附着、铺展和增殖）来增强周围神经再生的有前景的策略。目的是确定有效的操作方法，这些方法简单且易于在临床条件下用于神经再生和修复。
Zotero 插件
