He Bifang, Chai Guoshi, Duan Yaocong, Yan Zhiqiang, Qiu Liuyang, Zhang Huixiong, Liu Zechun, He Qiang, Han Ke, Ru Beibei, Guo Feng-Biao, Ding Hui, Lin Hao, Wang Xianlong, Rao Nini, Zhou Peng, Huang Jian
Center of Bioinformatics (COBI), Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
Center of Bioinformatics (COBI), Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China Center for Information in Biomedicine, University of Electronic Science and Technology of China, Chengdu 610054, China.
Nucleic Acids Res. 2016 Jan 4;44(D1):D1127-32. doi: 10.1093/nar/gkv1100. Epub 2015 Oct 25.
The BDB database (http://immunet.cn/bdb) is an update of the MimoDB database, which was previously described in the 2012 Nucleic Acids Research Database issue. The rebranded name BDB is short for Biopanning Data Bank, which aims to be a portal for biopanning results of the combinatorial peptide library. Last updated in July 2015, BDB contains 2904 sets of biopanning data collected from 1322 peer-reviewed papers. It contains 25,786 peptide sequences, 1704 targets, 492 known templates, 447 peptide libraries and 310 crystal structures of target-template or target-peptide complexes. All data stored in BDB were revisited, and information on peptide affinity, measurement method and procedures was added for 2298 peptides from 411 sets of biopanning data from 246 published papers. In addition, a more professional and user-friendly web interface was implemented, a more detailed help system was designed, and a new on-the-fly data visualization tool and a series of tools for data analysis were integrated. With these new data and tools made available, we expect that the BDB database would become a major resource for scholars using phage display, with improved utility for biopanning and related scientific communities.
BDB数据库（http://immunet.cn/bdb）是MimoDB数据库的升级版，MimoDB数据库曾在《核酸研究数据库》2012年刊中有所描述。重新命名后的BDB是生物淘选数据库（Biopanning Data Bank）的简称，旨在成为组合肽库生物淘选结果的门户网站。BDB最近一次更新是在2015年7月，包含从1322篇同行评审论文中收集的2904组生物淘选数据。它包含25,786个肽序列、1704个靶标、492个已知模板、447个肽库以及492个靶标-模板或靶标-肽复合物的晶体结构。对BDB中存储的所有数据进行了重新梳理，并为来自246篇已发表论文的411组生物淘选数据中的2298个肽添加了肽亲和力、测量方法和程序等信息。此外，还实现了一个更专业、用户更友好的网络界面，设计了一个更详细的帮助系统，并集成了一个新的即时数据可视化工具和一系列数据分析工具。有了这些新数据和工具，我们预计BDB数据库将成为使用噬菌体展示的学者的主要资源，对生物淘选及相关科学界的实用性也将得到提升。
