Fan Chengchao, Yu Siwei, Zhang Si, Ding Xiaojun, Su Jian, Cheng Zhigang
Department of Oral and Maxillofacial Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Medicine (Baltimore). 2017 Oct;96(42):e8182. doi: 10.1097/MD.0000000000008182.
The results of published studies about the relationships between folate intake and risk of head and neck squamous cell carcinoma (HNSCC) remained inconsistent. Hence, a comprehensive and dose-response meta-analysis was performed to clarify the association between folate intake and HNSCC risk.The electric searches of Pubmed, Medline, and EMBASE databases were performed to identify the studies examining the relationship between folate intake and HNSCC risk on April 5, 2017. According to the inclusion criteria, finally 9 studies were included in this meta-analysis. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of associations. Dose-response analysis was conducted to quantitate the relationship between dietary folate intake and HNSCC risk.The pooled OR for assessing the risk of HNSCC and folate intake in the highest level versus lowest level was 0.505 (95% CI 0.387-0.623). The linearity model of dose-response analysis indicated that with increased 100 μg/d folate intake, the risk of HNSCC decreased 4.3% degree (OR 0.957, 95% CI 0.935-0.980).These results indicate that folate is a protective nutrient against HNSCC carcinogenesis.
已发表的关于叶酸摄入量与头颈部鳞状细胞癌（HNSCC）风险之间关系的研究结果仍不一致。因此，进行了一项全面的剂量反应荟萃分析，以阐明叶酸摄入量与HNSCC风险之间的关联。2017年4月5日，对PubMed、Medline和EMBASE数据库进行了电子检索，以确定研究叶酸摄入量与HNSCC风险之间关系的研究。根据纳入标准，最终9项研究被纳入该荟萃分析。采用合并比值比（OR）和95%置信区间（CI）来评估关联强度。进行剂量反应分析以量化膳食叶酸摄入量与HNSCC风险之间的关系。评估最高水平与最低水平叶酸摄入量时HNSCC风险的合并OR为0.505（95%CI 0.387-0.623）。剂量反应分析的线性模型表明，叶酸摄入量每增加100μg/d，HNSCC风险降低4.3%（OR 0.957，95%CI 0.935-0.980）。这些结果表明，叶酸是一种预防HNSCC致癌作用的保护性营养素。
