Kaneda Tokinobu, Matsushita Michiko, Iwasaki Takeshi, Ishiguro Naoko, Koide Takashi, Hayashi Kazuhiko, Kitamura Yukisato
Department of Pathobiological Science and Technology, School of Health Science, Tottori University Faculty of Medicine, Yonago 683-8503, Japan ; †Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
†Division of Molecular Pathology, Department of Pathology, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
Yonago Acta Med. 2015 Sep;58(3):145-50. Epub 2015 Oct 14.
Skin cancer is an important complication in renal transplant recipients. Associations of transplant-related skin tumor with ultraviolet radiation, age at transplantation, type of immunosuppressant drug administered, and viral infection have been reported; however, the details remain unclear. We report a 61-year-old man who had underwent renal transplantation at 38 years of age and developed multiple skin tumors or squamous cell carcinomas (SCCs). Polymerase chain reaction (PCR) analyses of the patient's 12 tumors for viral DNAs of cutaneous or mucosal human papillomavirus (HPV) and 6 human polyomaviruses (MCPyV, trichodysplasia spinulosa-associated, BK, JC, KI and WU polyomaviruses) only detected cutaneous HPV-DNA in only 5 of the tumors; no other viruses were detected. Real-time PCR showed high loads of cutaneous HPV in 3 SCCs and very low loads of MCPyV in 9. Immunohistochemistry revealed no tumor cell expression for MCPyV-large T-antigen or mucosal HPV. Our report not only reconfirmed the association of cutaneous HPV5 with skin cancer in renal transplant recipients in previous studies but also showed no relevant association of 6 human polyomaviruses and mucosal HPV with skin tumors.
皮肤癌是肾移植受者的一种重要并发症。移植相关皮肤肿瘤与紫外线辐射、移植时的年龄、所使用的免疫抑制药物类型以及病毒感染之间的关联已有报道；然而，具体细节仍不清楚。我们报告一名61岁男性，他在38岁时接受了肾移植，并出现了多发性皮肤肿瘤或鳞状细胞癌（SCC）。对该患者的12个肿瘤进行聚合酶链反应（PCR）分析，检测皮肤或黏膜人乳头瘤病毒（HPV）以及6种人类多瘤病毒（MCPyV、棘状毛发发育异常相关多瘤病毒、BK、JC、KI和WU多瘤病毒）的病毒DNA，仅在5个肿瘤中检测到皮肤HPV-DNA；未检测到其他病毒。实时PCR显示，3个SCC中皮肤HPV载量高，9个中MCPyV载量极低。免疫组织化学显示，肿瘤细胞未表达MCPyV大T抗原或黏膜HPV。我们的报告不仅再次证实了先前研究中皮肤HPV5与肾移植受者皮肤癌之间的关联，还表明6种人类多瘤病毒和黏膜HPV与皮肤肿瘤无相关关联。
