Department of Pediatrics, Division of Allergy and Immunology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Ill.
Center for Sleep and Circadian Biology, Department of Neurobiology, Northwestern University, Evanston, Ill.
J Allergy Clin Immunol. 2015 Nov;136(5):1170-7. doi: 10.1016/j.jaci.2015.08.028.
Children with atopic dermatitis (AD) experience significant sleep disruption, and clinically, the disease is noted to worsen in a circadian manner at night. Epidemiologic findings highlight many negative consequences of AD, such as impaired linear growth, which is uniquely related to disturbed sleep. Clinical guidelines currently recommend assessing sleep in patients with AD as a crucial parameter of disease control with appropriate treatment. In this review we describe our current understanding of the roles of sleep cycles and circadian rhythms in the nighttime exacerbation of AD (nocturnal eczema). We present a schematic to explain the mechanism of nocturnal eczema. Treatment options for sleep disturbance and future directions for research are discussed in the context of AD.
患有特应性皮炎（AD）的儿童会经历明显的睡眠中断，临床上，这种疾病在夜间以昼夜节律的方式恶化。流行病学研究结果强调了 AD 的许多负面影响，例如线性生长受损，这与睡眠障碍有关。临床指南目前建议评估 AD 患者的睡眠，作为控制疾病的重要参数，并进行适当的治疗。在这篇综述中，我们描述了我们目前对睡眠周期和昼夜节律在 AD（夜间湿疹）夜间恶化中的作用的理解。我们提出了一个示意图来解释夜间湿疹的发病机制。讨论了针对睡眠障碍的治疗选择和 AD 研究的未来方向。
