通过重氮化合物的卡宾转移实现烷烃和芳烃中低反应性C(sp(3))-H和C(sp(2))-H键的催化官能团化。
Catalytic functionalization of low reactive C(sp(3))-H and C(sp(2))-H bonds of alkanes and arenes by carbene transfer from diazo compounds.
作者信息
Caballero Ana, Díaz-Requejo M Mar, Fructos Manuel R, Olmos Andrea, Urbano Juan, Pérez Pedro J
机构信息
Laboratorio de Catálisis Homogénea, Unidad Asociada al CSIC, CIQSO-Centro de Investigación en Química Sostenible and Departamento de Química, Universidad de Huelva, Campus de El Carmen 21007 Huelva, Spain.
出版信息
Dalton Trans. 2015 Dec 21;44(47):20295-307. doi: 10.1039/c5dt03450g. Epub 2015 Nov 16.
The direct functionalization of low reactive C(sp(3))-H and C(sp(2))-H bonds of alkanes and arenes, respectively, by metal-induced carbene transfer from diazo compounds is reviewed. To date, this methodology has enabled the incorporation of CR(1)R(2) moieties from N2[double bond, length as m-dash]CR(1)R(2) in a chemo, regio, enantio or diastereoselective manner in those substrates with the appropriate selection of metal and ligands.
本文综述了通过金属介导的重氮化合物卡宾转移反应，分别对烷烃中低活性的C(sp(3))-H键和芳烃中低活性的C(sp(2))-H键进行直接官能团化的研究。迄今为止，通过适当选择金属和配体，该方法已能够以化学、区域、对映或非对映选择性的方式，将来自N2[双键，长度如m短划线]CR(1)R(2)的CR(1)R(2)基团引入到这些底物中。
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