Haag Philippe A, Steiger-Ronay Valerie, Schmidlin Patrick R
Private Practice, Zahnarztpraxis an der Murg, Metzgerstrasse 1, Frauenfeld CH 8500, Switzerland.
Center of Dental Medicine, Clinic of Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, Zürich CH 8032, Switzerland.
Int J Mol Sci. 2015 Nov 13;16(11):27327-38. doi: 10.3390/ijms161126027.
Periodontitis, an inflammatory disease, is caused by biofilms with a mixed microbial etiology and involves the progressive destruction of the tooth-supporting tissues. A rising number of studies investigate the clinical potential of photodynamic therapy (PDT) as an adjunct during active therapy. The aim of the present review was to evaluate the available literature for the in vitro antimicrobial efficacy of photodynamic therapy focusing on the periodontopathogenic bacteria Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Fusobacterium nucleatum. The focused question was: "Is it possible to decrease (at least 3 log steps or 99.9%) or even eliminate bacterial growth by photodynamic therapy in vitro when compared to untreated control groups or control groups treated by placebo?" In general, PDT resulted in a substantial reduction of surviving bacteria. However, not all studies showed the desired reduction or elimination. The ranges of log10-reduction were 0.38 (58%) to a complete eradication (100%) for P. gingivalis, 0.21 (39%) to 100% for A. actinomycetemcomitans and 0.3 (50%) to 100% for F. nucleatum. In conclusion, further and particularly more comparable studies are needed to evaluate if PDT can be clinically successful as an adjuvant in periodontal therapy.
牙周炎是一种炎症性疾病，由具有混合微生物病因的生物膜引起，涉及牙齿支持组织的渐进性破坏。越来越多的研究探讨光动力疗法（PDT）作为积极治疗期间辅助手段的临床潜力。本综述的目的是评估关于光动力疗法对牙周病原菌伴放线聚集杆菌、牙龈卟啉单胞菌和具核梭杆菌的体外抗菌效果的现有文献。重点问题是：“与未治疗的对照组或接受安慰剂治疗的对照组相比，光动力疗法在体外是否有可能减少（至少3个对数级或99.9%）甚至消除细菌生长？”总体而言，光动力疗法导致存活细菌大量减少。然而，并非所有研究都显示出预期的减少或消除效果。牙龈卟啉单胞菌的对数减少范围为0.38（58%）至完全根除（100%），伴放线聚集杆菌为0.21（39%）至100%，具核梭杆菌为0.3（50%）至100%。总之，需要进一步开展更多具有可比性的研究，以评估光动力疗法作为牙周治疗辅助手段在临床上是否能够取得成功。
