Mansouri-Tehrani Hajar-Alsadat, Rabbani-Khorasgani Mohammad, Hosseini Sayyed Mohsen, Mokarian Fariborz, Mahdavi Hoda, Roayaei Mahnaz
Department of Biotechnology, University of Isfahan, Isfahan, Iran.
Department of Biology, University of Isfahan, Isfahan, Iran.
J Res Med Sci. 2015 Jul;20(7):679-83. doi: 10.4103/1735-1995.166224.
Radiotherapy is frequently used in treatment approaches of pelvic malignancies. Nevertheless, it has some known systemic effects on blood cells and the immune system that possibly results in their susceptibility to infection. Probiotics are live microbial food ingredients that provide a health advantage to the consumer. Honey has prebiotic properties. The aim of this clinical trial was to investigate probable effects of probiotic or probiotics plus honey on blood cell counts and serum IgA levels in patients receiving pelvic radiotherapy.
Sixty-seven adult patients with pelvic cancer were enrolled. Patients were randomized to receive either: (1) Probiotic capsules (including: Lactobacillus casei, Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus bulgaricus, Bifidobacterium breve, Bifidobacterium longum, and Streptococcus thermophiles) (n = 22), (2) probiotic capsules plus honey (n = 21) or (3) placebo capsules (n = 24) all for 6 weeks. Blood and serum samples were collected for one week before radiotherapy and 24-72 h after the end of radiotherapy.
White blood cells (WBC), red blood cells (RBC), platelet counts, and serum IgA level were not significantly changed in patients taking probiotic (alone or plus honey) during pelvic radiotherapy. The mean decrease in RBC count was 0.52, 0.18, and 0.23 × 10(6) cells/μL, WBC count was 2.3, 1.21, and 1.34 × 10(3) cells/μL and platelet count was, 57.6, 53.3, and 66.35 × 10(3) cells/μL for the probiotic, probiotic plus honey, and placebo groups, respectively. The mean decrease of serum IgA was 22.53, 29.94, and 40.73 mg/dL for the probiotic, probiotic plus honey, and placebo groups, respectively.
The observed nonsignificant effect of probiotics may be in favor of local effects of this product in the gut rather than systemic effects, however, as a trend toward a benefit was indicated, further studies are necessary in order to extract effects of probiotics or probiotic plus honey on hematologic and immunologic parameters in patients receiving pelvic radiotherapy.
放射疗法常用于盆腔恶性肿瘤的治疗。然而，它对血细胞和免疫系统有一些已知的全身影响，这可能导致患者易受感染。益生菌是对消费者具有健康益处的活微生物食品成分。蜂蜜具有益生元特性。本临床试验的目的是研究益生菌或益生菌加蜂蜜对接受盆腔放疗患者血细胞计数和血清IgA水平的可能影响。
招募了67名成年盆腔癌患者。患者被随机分为三组，分别接受：（1）益生菌胶囊（包括：干酪乳杆菌、嗜酸乳杆菌、鼠李糖乳杆菌、保加利亚乳杆菌、短双歧杆菌、长双歧杆菌和嗜热链球菌）（n = 22），（2）益生菌胶囊加蜂蜜（n = 21）或（3）安慰剂胶囊（n = 24），疗程均为6周。在放疗前一周以及放疗结束后24 - 72小时采集血液和血清样本。
接受盆腔放疗期间，服用益生菌（单独或加蜂蜜）的患者白细胞（WBC）、红细胞（RBC）、血小板计数和血清IgA水平均无显著变化。益生菌组、益生菌加蜂蜜组和安慰剂组的红细胞计数平均下降分别为0.52、0.18和0.23×10⁶个细胞/μL，白细胞计数平均下降分别为2.3、1.21和1.34×10³个细胞/μL，血小板计数平均下降分别为57.6、53.3和66.35×10³个细胞/μL。益生菌组、益生菌加蜂蜜组和安慰剂组的血清IgA平均下降分别为22.53、29.94和40.73mg/dL。
观察到的益生菌无显著作用可能有利于该产品在肠道的局部作用而非全身作用，然而，由于显示出有益的趋势，有必要进一步研究以明确益生菌或益生菌加蜂蜜对接受盆腔放疗患者血液学和免疫学参数的影响。
