Tian Yang, Li Ming, Song Wei, Jiang Rui, Li Yan Qing
Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250012, P.R. China.
Department of Gastroenterology, Shandong University, Qilu Hospital, Jinan, Shandong 250012, P.R. China.
Oncol Lett. 2019 Mar;17(3):2836-2848. doi: 10.3892/ol.2019.9906. Epub 2019 Jan 8.
Chemotherapy damages the intestinal mucosa, causing adverse gastrointestinal reactions. reduces the incidence of diarrhea in digestive diseases, including inflammatory bowel disease. Therefore, the aim of the present study was to investigate the role of in patients undergoing chemotherapy. A total of 41 participants with lung cancer were enrolled, and divided into the (CB) or placebo group using 1:1 randomization to obtain 20 CB and 21 placebo participants. On the first and last day of the 3-week intervention, blood and stool samples were collected and analyzed. To analyze stool flora, 16S ribosomal RNA sequencing was performed. The incidence of chemotherapy-induced diarrhea was lower in the CB group compared with the placebo group. The lymphocyte count and platelet/lymphocyte ratio (PLR) was markedly altered between the two groups. Neutrophil/lymphocyte ratio (NLR) and PLR decreased within the CB group. At week 3, the lymphocyte/monocyte ratio (LMR) was higher in the CB group compared with the placebo group. Alterations in lymphocyte subsets and immunoglobulin levels were not significantly different. Albumin (ALB) level and weight did not differ significantly between the two groups. At 3 weeks the total flora diversity did not decrease in either group. Phyla in the CB group varied slightly, while the proportion of in the placebo group decreased significantly. No statistically significant difference was observed between the two groups, though the genera producing short-chain fatty acids tended to increase, and the pathogenic genera tended to decrease in the CB group, which was almost the opposite of the observation in the placebo group. Operational taxonomy unit analysis revealed a notable increase in beneficial flora, including the and genera of the CB group, compared with the placebo group. The present study highlighted that reduced chemotherapy-induced diarrhea in patients with lung cancer, reduced the systemic inflammatory response system and encouraged homeostatic maintenance.
化疗会损害肠道黏膜，引发不良的胃肠道反应。降低包括炎症性肠病在内的消化系统疾病中腹泻的发生率。因此，本研究的目的是调查其在接受化疗患者中的作用。共招募了41名肺癌患者，并采用1:1随机分组法分为CB组或安慰剂组，分别有20名CB组患者和21名安慰剂组患者。在为期3周的干预的第一天和最后一天，采集血样和粪便样本并进行分析。为分析粪便菌群，进行了16S核糖体RNA测序。与安慰剂组相比，CB组化疗引起的腹泻发生率较低。两组之间淋巴细胞计数和血小板/淋巴细胞比率（PLR）有明显变化。CB组中性粒细胞/淋巴细胞比率（NLR）和PLR降低。在第3周时，CB组的淋巴细胞/单核细胞比率（LMR）高于安慰剂组。淋巴细胞亚群和免疫球蛋白水平的变化无显著差异。两组之间白蛋白（ALB）水平和体重无显著差异。在3周时，两组的总菌群多样性均未降低。CB组的菌门略有变化，而安慰剂组中的比例显著下降。两组之间未观察到统计学上的显著差异，尽管CB组中产生短链脂肪酸的菌属有增加趋势，而致病菌属有减少趋势，这与安慰剂组的观察结果几乎相反。操作分类单元分析显示，与安慰剂组相比，CB组中有益菌群显著增加，包括和属。本研究强调，可减少肺癌患者化疗引起的腹泻，降低全身炎症反应系统并促进内环境稳态维持。
